摘要
Introduction To study the effects of aerobic exercise on lipid metabolism,endothelial function,and oxidative stress reaction in postmenopausal women,in order to prevent and control atherosclerosis.Methods Thirty-two women with natural menopause were randomly divided into an exercise group and a control group.Participants in the exercise group(n=16)took part in a 3-month aerobic training program according to their exercise pre-scription,while participants in the control group(n=16)maintained their usual lifestyles.Lipids,endothelial function,and oxidative stress-related indicators were measured before and after the intervention.Results After 3 months of aerobic training at an intensity of 50-60%of cardiorespiratory fitness,serum total cholesterol and low-density lipoprotein cholesterol decreased significantly(P<0.05),and high-density lipoprotein cholesterol increased significantly(P<0.01).A significant reduction in endothelin(P<0.01)and a significant increase in nitric oxide(P<0.05)were also observed.The training intervention also delayed the increase in homocysteine and cysteine aspartate-specific protease-3 in postmenopausal women.Conclusions Aerobic exercise had a positive effect on blood lipids,endothelial function,and oxidative stress of postmeno-pausal women,and these changes may mitigate the risk of atherosclerosis occurrence.Similar exercise programs could be used as a primary atherosclerosis prevention strategy for postmenopausal women.
基金
supported by the General Administration of Sport of China(2017B064)
Beijing Sport University(2018GJ014)。
