二甲双胍对肠道菌群的调节作用及其抗炎机制的研究进展

Research progress in regulation of metformin on intestinal flora and study of its anti-inflammatory mechanisms

目的综述二甲双胍对肠道菌群的调节作用,总结二甲双胍通过调节肠道菌群发挥抗炎作用的机制。方法通过查阅国内外文献,归纳了二甲双胍对肠道菌群的调节作用和基于该机制产生的抗炎作用。结果二甲双胍能够增加益生菌的数量、减少致病菌的丰度。进而通过稳定胃肠道黏膜、促进短链脂肪酸(short-chain fatty acid,SCFA)的生成、调节炎症细胞因子、调节法尼醇X受体(farnesoid x receptor,FXR)、调节金属蛋白等方式产生抗炎作用。结论二甲双胍能通过调节肠道菌群产生抗炎作用,可作为慢性炎症相关性疾病的潜在治疗。

Objective To summarize the most recent advances in the regulatory effect of metformin on intestinal flora and its anti-inflammatory mechanisms.Methods The regulatory effect of metformin on intestinal flora and its anti-inflammatory mechanisms were summarized by consulting literatures.Results Metformin could increased the number of probiotics and reduced the abundance of pathogenic bacteria.Furthermore,it produced anti-inflammatory effects by stabilizing gastrointestinal mucosa,promoting the production of short-chain fatty acids(SCFA),regulating inflammatory cytokines,farnesoid X receptor(FXR),and metalloproteins.Conclusion Metformin can produce anti-inflammatory effect by regulating intestinal flora,which can be used as a potential treatment for chronic inflammation-related diseases.