正交试验法优化山楂咀嚼片的包衣工艺

Orthogonal Test Method Prefers Film Coating Process Parameters of Hawthorn Chewable Tablets

为优化山楂咀嚼片的包衣工艺,采用L_(9)(3^(4))正交试验法,以包衣合格率为考察指标,对进风温度、包衣增重、滚筒转速等3个因素进行考察,优化包衣工艺。结果表明,最佳包衣工艺为喷浆转速3 r·min^(-1),进风温度55℃,包衣增重3%,滚筒转速7 r·min^(-1)。此条件下制得的包衣片色泽均匀、光滑完整,表明优选的包衣工艺可行、简便、稳定。

In order to optimize the film coating process of hawthorn chewable tablets,the L_(9)(3^(4))orthogonal test method was used,and three factors,including air inlet temperature,coating weight gain,and drum rotation speed,were investigated based on the coating qualification rate,and the optimization of the coating was carried out.The results show that the optimal film coating process is the spraying speed of 3 r·min^(-1),the inlet air temperature of 55℃,the coating weight gain of 3%,and the drum speed of 7 r·min^(-1).The coated tablets prepared under this condition are uniform in color,smooth and complete,indicating that the preferred film coating process is feasible,simple and stable.