诊断试验准确性比较研究的偏倚评估工具--QUADAS-C

QUADAS-C—A tool for assessing risk of bias regarding Quality Assessment of Diagnostic Accuracy Studies-Comparative

本文介绍了诊断试验准确性比较研究的偏倚评估工具(QUADAS-C)的主要内容,阐述了QUADAS-C与QUADAS-2的联系与区别,同时介绍了如何将QUADAS-C与QUADAS-2结合使用及如何呈现评价结果。QUADAS-C在QUADAS-2的基础上,共扩展14个标志性问题,形成4个关键领域(病例选择、待评价试验、金标准、病例流程和待评价试验与金标准之间的时间间隔)。与QUADAS-2不同的是,QUADAS-C各领域第一个标志性问题的回答均需结合QUADAS-2的评价结果;此外,QUADAS-C仅评价原始研究的偏倚风险而不包含适用性评价。完成QUADAS-C评价最终得出原始研究每个领域偏倚风险为“低”“高”或“不清楚”的结果。

This paper introduced the Quality Assessment of Diagnostic Accuracy Studies-Comparative(QUADAS-C),illustrated the comparison with the QUADAS-2,and using QUADAS-C together with QUADAS-2 to present QUADAS-C results through systematic reviews.Like the domain for QUADAS-2,QUADAS-C retained four domains,including patient selection,index test,reference standard,flow,and timing,and comprised additional questions for each QUADAS-2 part.Unlike the QUADAS-2 tool,the starting question of each domain for QUADAS-C was designed to summarize the risk of biased information captured by QUADAS-2.QUADAS-C only dealt with the risk of bias but did not include the part of concerns regarding applicability.The answers to signaling questions for each domain of QUADAS-C would lead to a'low''high'or'unclear'risk of biased judgment for the original study.