血清cTnI、CK-MB、CRP、IL-6水平与急性心肌梗死患者幽门螺杆菌感染的关系

Relationship between serum cTnI,CK-MB,CRP,IL-6 levels and Helicobacter pylori infection in patients with acute myocardial infarction

目的探讨血清肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、C反应蛋白(CRP)、白细胞介素(IL)-6水平与急性心肌梗死(AMI)患者幽门螺杆菌(Hp)感染的关系。方法选取2018年3月至2020年10月于都县中医院收治的112例AMI患者作为研究组,另选取同期在于都县中医院健康体检的志愿者100例作为对照组,检测并比较两组研究对象血清cTnI、CK-MB、CRP、IL-6水平及Hp免疫球蛋白(Ig)G水平。根据Hp感染情况又将研究组AMI患者分为Hp阳性组(70例)和Hp阴性组(42例),比较Hp阳性组和Hp阴性组患者血清cTnI、CK-MB、CRP、IL-6水平。以Pearson相关分析AMI患者血清cTnI、CK-MB、CRP、IL-6水平与Hp IgG水平的相关性。结果研究组患者Hp IgG水平及Hp阳性率均高于对照组,差异均有统计学意义(P<0.05)。研究组患者血清cTnI、CK-MB、CRP、IL-6水平均高于对照组,差异均有统计学意义(P<0.05)。Hp阳性组患者血清cTnI、CK-MB、CRP、IL-6水平均高于Hp阴性组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,AMI患者血清cTnI、CK-MB、CRP、IL-6水平与Hp IgG水平均呈正相关(P<0.05)。结论AMI患者血清cTnI、CK-MB、CRP、IL-6水平与Hp感染密切相关,Hp感染与血清炎性反应互相影响,可能促进AMI病情发展。

Objective To explore the relationship between serum troponin I(cTnI),creatine kinase isoenzyme(CK-MB),C-reactive protein(CRP),interleukin(IL)-6 levels and Helicobacter pylori(Hp)infection in patients with acute myocardial infarction(AMI).Methods A total of 112 AMI patients admitted to Yudu County Hospital of Traditional Chinese Medicine from March 2018 to October 2020 were selected as the research group,and another 100 healthy volunteers who underwent physical examination in the Yudu County Hospital of Traditional Chinese Medicine during the same period were selected as the control group.Serum cTnI,CK-MB,CRP,IL-6 levels and Hp immunoglobulin(Ig)G were detected and compared between the two groups.In addition,patients in the research group were divided into Hp positive group(70 cases)and Hp negative group(42 cases)according to Hp infection status,and the serum cTnI,CK-MB,CRP and IL-6 levels in the Hp negative group and Hp positive group were compared.Pearson correlation was used to analyze the correlation between serum cTnI,CK-MB,CRP,IL-6 levels and Hp IgG level in patients with AMI.Results The levels of Hp IgG and the positive rate of Hp in the research group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of cTnI,CK-MB,CRP and IL-6 in the research group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of cTnI,CK-MB,CRP,and IL-6 in the Hp positive group were higher than those in the Hp negative group,and the differences were statistically significant(P<0.05).The results of Pearson correlation analysis showed that serum cTnI,CK-MB,CRP,IL-6 levels were positively correlated with Hp IgG level in AMI patients(P<0.05).Conclusion Serum cTnI,CK-MB,CRP and IL-6 levels are closely related to Hp infection in patients with AMI,and the interaction between Hp infection and serum inflammatory response may promote the development of AMI.