系统性红斑狼疮合并下肢静脉血栓的相关因素分析

Analysis of related factors in systemic lupus erythematosus complicated with lower limb ve⁃nous thrombosis

目的:分析系统性红斑狼疮(SLE)合并下肢静脉血栓的危险因素。方法:选取2017年8月至2020年8月北海市人民医院风湿免疫科收治的SLE患者258例,根据中华医学会外科学分会血管外科学组与呼吸病学会制定的下肢静脉血栓诊断标准统计下肢静脉血栓发生率,并根据有无合并下肢静脉血栓分为SLE合并下肢静脉血栓组(n=50)和SLE组(n=208),比较两组临床资料,并采用多因素Logistic回归分析分析SLE合并下肢静脉血栓的危险因素。结果:两组年龄、血小板(PLT)、C反应蛋白(CRP)、D二聚体(DD)、纤维蛋白原(FIB)、血红蛋白(Hb)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、白蛋白(ALB)、24 h尿蛋白定量(尿24 h Pro)、狼疮肾炎、肾功能不全、肾性高血压及肾病综合征比较差异具有统计学意义(P<0.05);多因素Logistic回归分析结果显示,年龄、PLT、CRP、DD、FIB、Hb、TC、TG、LDL-C、ALB、24 h Pro、肾功能不全为SLE并发下肢静脉血栓的独立危险因素(P<0.05)。结论:针对SLE合并下肢静脉血栓的危险因素,临床应进行密切监测,并给予针对性措施,以减少下肢静脉血栓发生。

Objective:To analyze the risk factors for systemic lupus erythematosus(SLE)complicated with lower extremity venous thrombosis.Methods:A total of 258 patients with SLE patients who were admitted to the Department of Rheumatology and Immunology,Beihai People's Hospital from August 2017 to August 2020 were selected.The incidence rate of venous thrombosis of lower extremities was calculated according to the diagnostic criteria for lower extremity venous thrombosis formulated by the Vascular Surgery Group of the Chinese Medical Association and the Society of Respiratory Diseases,and the patients were divided into SLE combined with lower extremity venous thrombosis group(n=50)and SLE group(n=208).The clinical data of two groups were compared,and multivariate Logistic regression analysis was used to analyze the risk factors of SLE complicated with lower extremity venous thrombosis.Results:There were statistically significant differences in age,platelet(PLT),C-reactive protein(CRP),D-dimer(D-D),fibrinogen(FIB),hemoglobin(Hb),total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),albumin(ALB),24 h urinary protein quantification(24 h Pro),lupus nephritis,renal insufficiency,renal hypertension and nephrotic syndrome between the two groups(P<0.05).Multivariate Logistic regression analysis showed that the age,PLT,CRP,DD,FIB,Hb,TC,TG,LDL-C,ALB,24 h Pro,and renal insufficiency were independent risk factors for SLE complicated with lower extremity venous thrombosis(P<0.05).Conclusion:For the risk factors of SLE complicated with lower extremity venous thrombosis,close clinical monitoring should be carried out,and targeted measures should be given to reduce the occurrence of lower extremity venous thrombosis.