肿瘤酸性微环境对相关免疫成分的作用研究进展

Research progress on the effect of tumor microenvironment on related immune components

在肿瘤微环境中,由于肿瘤细胞代谢的重新编程,代谢模式由原来的氧化磷酸化转变为糖酵解,即使在有氧的条件下也是如此,即沃伯格效应(Warburg effect)。为避免细胞内酸化,肿瘤细胞将有氧糖酵解产生的乳酸排至肿瘤微环境中,使肿瘤微环境呈现出酸性。免疫细胞是肿瘤微环境中的一种重要组分,酸性微环境可能会对肿瘤免疫监视的不同组成部分产生不同的影响,最终导致免疫逃逸和癌症进展。本文综述了酸性条件下驱动相关免疫组分“失效”的可能机制,旨在阐明免疫治疗在肿瘤发生和发展中的潜在作用。

In tumor microenvironment,the metabolic mode changes from oxidative phosphorylation to glycolysis due to the reprogramming of tumor cell metabolism,even under aerobic conditions,namely Warburg effect.In order to avoid intracellular acidification,tumor cells discharge the lactic acid produced by aerobic glycolysis into the tumor microenvironment,making the tumor microenvironment acidic.Immune cells are an important component of tumor microenvironment,acidic microenvironment may have different effects on different components of tumor immune surveillance,and eventually lead to immune escape and cancer progression.This paper reviews the possible mechanism of driving the"failure"of related immune components under acidic conditions,in order to clarify the potential role of immunotherapy in the occurrence and development of tumors.