音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响研究

Effects of Music Therapy Assisted Anagliptin on Glycolipid Metabolism in Patients with Type 2 Diabetes

背景音乐治疗作为新兴的治疗方法,在慢性疾病康复中的应用逐渐兴起,且日益得到重视。但音乐治疗对糖尿病康复的效果研究尚少见报道。目的观察音乐辅助阿格列汀对2型糖尿病患者糖脂代谢的影响。方法选取2019年10月至2021年2月在中国康复研究中心北京博爱医院内分泌科门诊就诊的口服药物血糖控制不佳的2型糖尿病患者65例。采用随机数字表法将患者分为A组(n=35)和B组(n=30),两组患者均保持原有饮食、运动习惯。A组在原治疗(药物种类、剂量不变)基础上联用阿格列汀片治疗,B组在A组基础上给予音乐辅助治疗。两组患者均连续治疗12周。比较治疗前及治疗12周后两组患者空腹血糖(FPG)、糖化血红蛋白(HbA_(1c))、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、餐后2 h血糖(2 hPG)、超敏C反应蛋白(hs-CRP)、游离脂肪酸(FFA)、胰岛素抵抗指数(HOMA-IR)、β细胞功能分泌指数(HOMA-β);观察患者治疗过程中不良反应发生情况。结果两组试验过程中因药物不良反应均剔除1例患者,A组、B组最终分别有34、29例患者完成试验。B组患者治疗12周后2 hPG低于A组(P<0.05)。治疗12周后两组患者FPG、HbA_(1c)、2 hPG均低于组内治疗前,HOMA-β高于组内治疗前(P<0.05);治疗12周后B组患者LDL-C、TC均低于组内治疗前(P<0.05)。两组均未发生低血糖事件。结论音乐辅助阿格列汀较无音乐辅助更能降低2型糖尿病患者的餐后血糖,改善血脂情况。需要强调的是,音乐治疗的效果一定是在饮食控制、适当运动、合理用药的基础上。

Background Music therapy,as an emerging treatment,has a gradually evolving role in the rehabilitation of chronic diseases and is gaining increasing attention.But there are few studies on the effects of music therapy on diabetes rehabilitation.Objective To observe the effects of music assisted anagliptin on glycolipid metabolism in patients with type 2 diabetes.Methods Sixty five type 2 diabetic patients with poor glycemic control on oral agents who visited the outpatient clinic of Department of Endocrinology,Boai Hospital,China Rehabilitation Research Center,from October 2019 to February 2021 were selected.Patients were divided into group A(n=35)and group B(n=30)by random numbers,and patients in both groups maintained their original diet and exercise habits.Group A was treated with anagliptin tablets in combination with the original treatment(drug type,dose unchanged),while group B was given music adjuvant therapy on the basis of group A.Patients in both groups were treated continuously for 12 weeks.Fasting plasma glucose(FPG),glycated hemoglobin(HbA_(1c)),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),uric acid(UA),2 h postprandial plasma glucose(2 hPG),hypersensitivity C-reactive protein(hs-CRP),free fatty acids(FFA),insulin resistance index(HOMA-IR),βCell function secretion index(HOMA-β)before and 12 weeks after treatment were compared between the two groups.The patients were observed for the occurrence of adverse reactions during the treatment.Results One patient was eliminated from the trial because of adverse drug reactions during the course of the trial in both groups,and 34 and 29 patients finally completed the trial in groups A and B,respectively.Patients in group B had lower 2 hPG than those in group A after 12 weeks of treatment(P<0.05).FPG,HbA_(1c),and 2 hPG were lower in both groups after 12 weeks of treatment whereas HOMA-βwere higher after treatment(P<0.05);LDL-C and TC of group B patients after 12 weeks of treatment were lower(P<0.05).No hypoglycemic events occurred in either group.Conclusion Music-assisted alagliptin can reduce postprandial blood glucose and improve lipid profile of type 2 diabetes patients more than that without music-assisted alagliptin.It also needs to be emphasized that the effects of music therapy must be based on diet control,proper exercise,and rational medication.