中药治疗奥沙利铂神经毒性的用药规律分析

Analysis of the Medication Rules of Traditional Chinese Medicine in the Treatment of Oxaliplatin Neurotoxicity

目的:探究中医治疗奥沙利铂所致周围神经毒性的用药规律。方法:检索中国知网(CNKI)近15年中药治疗奥沙利铂周围神经毒性的相关文献,运用Excel建立数据库,中医传承辅助平台(V2.5)及SPSS Statistics 21.0,分别统计出用药频数、性味归经、关联规则、核心处方及聚类分析、因子分析。结果:共纳入文献70篇,收集处方70剂,共有中药145味,累计频数771次。其中,使用频数≥5的中药37味,以当归(49,8.53%)最为常见;药性以温(382,52.76%)、平(175,24.17%)为主,药味以甘(441,39.48%)、辛(289,25.87%)为主;归经分类以肝经(22.55%)最多、脾经(19.80%)次之。通过高频药物聚类分析得到4类药物组合,关联规则分析得到20对高频药对组合以及11对置信度较高的关联组合,基于复杂系统熵聚类得到8对核心组合及4对新处方,因子分析提取出8个公因子。结论:目前,中医治疗奥沙利铂所致周围神经毒性以补气药、补血药、活血化瘀药频率最高。

Objective:To explore the medication rule of traditional Chinese medicine in the treatment of peripheral neurotoxicity caused by oxaliplatin.Methods:The Chinese National Knowledge Infrastructure (CNKI) was searched for related literatures on the treatment of peripheral neurotoxicity of oxaliplatin by traditional Chinese medicine in the past 15 years.Sexual taste and classics,association rules,core prescriptions and cluster analysis,factor analysis.Results:A total of 70 literatures were included,70 prescriptions were collected,there were 145 traditional Chinese medicines,and the cumulative frequency was 771 times.Among them,there are 37 traditional Chinese medicines with frequency ≥ 5,among which Angelica sinensis (49,8.53%) is the most common;the medicinal properties are mainly warm (382,52.76%),flat (175,24.17%),and the medicinal taste is sweet (441,39.48%),Xin (289,25.87%) were the main ones;the liver meridian (22.55%) was the most,followed by the spleen meridian (19.80%).Four types of drug combinations were obtained through high-frequency drug clustering analysis,20 high-frequency drug-pair combinations and 11 high-confidence association combinations were obtained by association rule analysis,and 8 pairs of core combinations and 4 pairs of new combinations were obtained based on complex system entropy clustering.Prescription,factor analysis extracted 8 common factors.Conclusion:At present,in the treatment of peripheral neurotoxicity caused by oxaliplatin in traditional Chinese medicine,Qi-tonifying drugs,blood-tonifying drugs,and blood-activating and stasis-removing drugs have the highest frequency.