肾炎康复片联合前列地尔治疗早期糖尿病肾病患者的效果

Effects of nephritis rehabilitation tablets combined with Alprostadil in treatment of patients with early diabetic nephropathy

目的:观察肾炎康复片联合前列地尔治疗早期糖尿病肾病患者的效果。方法:选取106例早期糖尿病肾病患者为研究对象,按照随机数字表分法分为对照组和观察组各53例。在常规治疗基础上,对照组采用前列地尔治疗,观察组在对照组基础上联合肾炎康复片治疗,比较两组临床疗效、治疗前后血糖指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)及餐后2 h血糖(2hPG)]水平、肾功能指标[血清尿素氮(BUN)、血肌酐(SCr)、24 h尿白蛋白(24 h UP)]水平和血液流变学指标[血浆黏度(PV)、全血高切黏度(HBV)、全血低切黏度(LBV)]水平。结果:观察组治疗总有效率为92.45%(49/53),高于对照组的75.47%(40/53),差异有统计学意义(P<0.05);治疗后,观察组FBG、HbA1c和2hPG水平均低于对照组,差异有统计学意义(P<0.05);两组BUN、SCr和24hUP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组HBV、LBV和PV均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:肾炎康复片联合前列地尔治疗早期糖尿病肾病患者可提高治疗总有效率,降低血糖指标水平、肾功能指标水平和血液流变学指标水平,效果优于单纯前列地尔治疗。

Objective: To observe effects of nephritis rehabilitation tablets combined with Alprostadil in treatment of patients with early diabetic nephropathy. Methods: 106 patients with early diabetic nephropathy were selected as the research objects and were divided into control group and observation group according to the random number table method, 53 cases in each. Both groups received basic treatment. On this basis,the control group was treated with Alprostadil, while the observation group was treated with nephritis rehabilitation tablets on the basis of that of the control group. The clinical effects, the blood glucose index levels [fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), 2 h postprandial blood glucose(2hPG)], the renal function index levels [serum urea nitrogen(BUN), serum creatinine(SCr),24 h urinary albumin(24 hUP)], and the hemorheologic index levels [plasma viscosity(PV), whole blood high shear viscosity(HBV), whole blood low shear viscosity(LBV)] were compared between the two groups before and after the treatment. Results: The total effective rate of the observation group was 92.45%(49/53), which was higher than 75.47%(40/53) of the control group, and the difference was statistically significant(P<0.05). After the treatment, the levels of FBG,HbA1c and 2hPG in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). The levels of BUN, SCr and 24 h UP in the two groups were lower than those before the treatment, those of the observation group were lower than those of the control group, and the differences were statistically significant(P<0.05). Further, the levels of HBV, LBV and PV in the two groups were lower than those before the treatment, those of the observation group were lower than those of the control group, and the differences were statistically significant(P<0.05). Conclusions: Nephritis rehabilitation tablets combined with Alprostadil in the treatment of the patients with early diabetic nephropathy can improve the total effective rate of treatment and reduce the levels of blood glucose indexes, the renal function indexes and the hemorheologic indexes.Moreover, it is superior to single Alprostadil treatment.