川芎嗪单独及联合西药抗肿瘤作用研究进展

Anti-tumor Effect of Ligustrazine Alone and in Combination with Western Medicine:A Review

随着环境问题和人口老龄化越来越严重,全世界的癌症数量急剧增加。对于现代医学水平来说,癌症是无法根治的恶性疾病,具有转移率高、细胞增殖和侵袭能力强等特点。目前临床抗癌治疗主要包括化疗和放疗,但多数化疗药物可引发严重的不良反应。因此,高安全性的传统中药目前被广泛应用于抗癌治疗中,具有抑制癌细胞增殖、提高生存质量、延长寿命等作用。川芎嗪是由川芎中分离得到的一种生物碱,具有抗纤维化,抗氧化和抗肿瘤等药理作用。近年来,川芎嗪作为川芎生物碱的指标活性物质,其药理作用逐渐成为临床医学研究的热点之一,且抗肿瘤作用更受研究者关注。该文主要从川芎嗪诱导肿瘤细胞凋亡和自噬、抑制细胞增殖和迁移、逆转癌细胞的多重耐药性、抑制新生血管的形成等4个方面探讨了其抗癌作用,且在肝癌、胃癌、肺癌、直肠癌、膀胱癌、乳腺癌、卵巢癌等多种恶性肿瘤中均观察到抗肿瘤功效;此外川芎嗪还可联合顺铂、紫杉醇、鬼臼毒素、查尔酮、姜黄素等药物发挥抗肿瘤作用。为此,该研究基于川芎嗪抗肿瘤作用机制途径进行文献综述,以期为临床恶性肿瘤的治疗提供参考。

With serious environmental problems and the aging of population,the incidence of cancers worldwide has increased dramatically. For modern medicine,cancer is an incurable malignant disease with a high metastasis rate and strong cell proliferation and invasion ability. At present,clinical anti-cancer therapies mainly include chemotherapy and radiotherapy,but most chemotherapy drugs can cause serious side effects.Therefore,Chinese medicine with high safety has been widely used in anti-cancer treatment,which can inhibit the proliferation of cancer cells,improve the quality of life,and prolong life. Ligustrazine is a pyrazine alkaloid isolated and purified from Chuanxiong Rhizoma,which has pharmacological effects,such as anti-fibrosis,antioxidation,and anti-tumor. In recent years,ligustrazine,as an index active component of Chuanxiong Rhizoma alkaloids,has gradually become one of the hot spots in clinical medical research due to its pharmacological actions, and its anti-tumor effect has attracted more attention from researchers. The present study mainly investigated the anti-cancer effect of ligustrazine from the induction of tumor cell apoptosis and autophagy,inhibition of cell proliferation and migration,reversal of multidrug resistance of cancer cells,and inhibition of angiogenesis,and the anti-tumor efficacy was observed in various malignancies such as gastric cancer,lung cancer,rectal cancer,bladder cancer,breast cancer,and ovarian cancer. In addition,ligustrazine can be combined with cisplatin,paclitaxel,podophyllotoxin,chalcone,curcumin,and other drugs to exert an antitumor effect. This study conducted a literature review based on the anti-tumor mechanism of ligustrazine to provide a reference for the treatment of clinical malignancies.