摘要
To the Editor:Augmented renal clearance(ARC)refers to an enhanced elimination of circulating solutes,including drugs,by the kidneys at a rate statistically higher than normal.On the first day of intensive care unit(ICU)admission,ARC occurrence may predict continued creatinine clearance(CrCl)elevation for 1 day to several weeks.[1]ARC has a substantial adverse effect on renally cleared antibiotics'pharmacokinetics/pharmacodynamics.Treatment failure or worse outcomes are more frequent in ARC patients.Thus,a"one size fits all"approach to drug dosing in ARC patients is inappropriate;dosing requires adjustment for some variables.
基金
supported by grants from the Gansu Provincial Department of Education Higher School Innovation Ability Improvement Project(No.2019B-002)
the First Hospital of Lanzhou University Hospital Fund(No.ldyyyn2018-04)
the Chengguan District Science and Technology Plan Project(No.2020SHFZ0033)
the Wu Jie Ping Medical Foundation(No.320.6750.2020-04-42)
the Chengguan District Science and Technology Plan Project(No.2017SHFZ0038)。
