健康人群脉冲-阶跃-正弦试验结果的初步分析

Preliminary analysis of pulse-step-sine test results in healthy population

目的分析不同年龄健康人群脉冲-阶跃-正弦(pulse-step-sine,PSS)试验的特点,探讨其临床价值。方法2018年7月10日至2020年12月9日招募健康成人志愿者78名,其中男40名,女38名,按照年龄分为青年组(≤44岁)、中年组(45~59岁)和老年组(≥60岁)。应用I-portal NOTC转椅系统进行PSS检测,分析阶跃和正弦成分的增益、相位、不对称性以及斜率的临床特点。使用SPSS17.0软件对数据进行统计学分析。结果78名志愿者均完成检测。在同一年龄组,左向和右向的阶跃增益、斜率和正弦增益的差异均无统计学意义(P值均>0.05)。不同年龄组间进行两两比较发现:老年组相较于青年组,其左侧阶跃增益降低(P=0.006),而右侧差异无统计学意义(P>0.05);其左右两侧的斜率均降低,差异有统计学意义(P值分别为0.004、0.007)。老年组相较于中年组,其左右侧的斜率降低,差异有统计学差异(P值分别为0.040、0.014)。青年组和中年组的相对应参数差异无统计学意义(P值均>0.05)。结论PSS试验在不同年龄组健康人群有良好耐受性,可以检测双侧和单侧水平半规管的中频功能,以及已经代偿的单侧前庭功能低下,是一种新型前庭检测手段。

Objective To analyze the characteristics of pulse-step-sine(PSS)test in healthy people of different ages and to discuss its clinical value.Methods From July 10,2018 to December 9,2020,a total of 78 healthy volunteers,including 40 males and 38 females,were enrolled and divided into youth group,middle age group and old age group.The I Portal NOTC rotational-chair system(NKI)was applied for PSS detection to analyze the clinical characteristics of gain,phase,asymmetry,and slope of step and sinusoidal components.Statistical analysis was performed using SPSS17.0 software.Results In the same age group,there were no statistically significant differences in left and right step gain,slope gain and sine gain(All P values were greater than 0.05).Pairwise comparison between different age groups showed that there was no significant difference in the corresponding parameters between the youth group and the middle age group.Compared with young group,the old age group had a significantly lower step gain value in their left side(P<0.01)but not in the right side(P>0.05).The left and right slopes of the old age group were significantly lower than those of the young group and the middle group,and the differences were statistically significant(All P values<0.05).Conclusion The PSS test can detect bilateral and unilateral horizontal semicircular canal function with good tolerance in different age groups,better than the traditional rotational chair examination to determine the well-compensated unilateral vestibular function.PSS test is a new vestibular detection method.