阿魏酸和白芷提取物对1例额叶变异型阿尔茨海默病患者的临床疗效

Feru-guard Improves Cognitive Dysfunction in the Frontal Variant of Alzheimer's Disease:A Case Report

阿尔茨海默病(Alzheimer’s disease,AD)也被称为老年性痴呆,是一种伴有精神行为改变和日常生活能力减退的神经退行性疾病,β-淀粉样蛋白(amyloidβ-protein,Aβ)沉积形成的老年斑及过度磷酸化Tau蛋白形成的神经原纤维缠结(neurofibrillary tangles,NFTs)是其组织病理学特征。AD分为典型AD和非典型AD。后皮层变异性AD、Logopenic失语AD和额叶变异型AD(frontal variant of AD,Fv AD)均为非典型AD,其中FvAD临床明显特征是患者在痴呆的早期即出现额叶功能的严重受损。阿魏酸和白芷提取物(Feru-guard)是一种膳食补充剂,近年来在治疗痴呆伴发精神行为障碍(behavioral and psychological symptoms of dementia,BPSD)方面的疗效引起了相关学者的广泛关注。本文报道了Feru-guard治疗1例FvAD患者的临床疗效,并详细回顾了其诊治过程。

Alzheimer’s disease(AD, also known as senile dementia) is a neurodegenerative disease characterized by progressive cognitive decline associated with behavioral and psychological symptoms and the reduction of daily activities. The pathological characteristics of AD include the deposition of amyloid beta(Aβ), neurofibrillary tangles(NFTs). The International Working Group(IWG) has divided AD into two different types, the typical form and the atypical form, the latter including the posterior variant, the logopenic variant and the frontal variant AD(Fv AD). The most obvious clinical feature of patients with Fv AD is the severe impairment on frontal lobe function. Feru-guard, a dietary supplement containing ferulic acid and Angelica archangelica, has attracted much interest recently due to the discovery of beneficial effects in the treatment of behavioral and psychological symptoms of dementia(BPSD). Here we present a case of improvement of cognitive dysfunction in a patient with Fv AD after Feru-guard therapy.