银屑病样表现的移植物抗宿主病1例

A case of psoriasiform graft-versus-host disease

报告1例罕见的银屑病样表现的移植物抗宿主病。患者女,35岁,头面部、四肢伸侧、躯干出现红色斑块,上覆银白色鳞屑。患者患急性B淋巴细胞白血病1年余,9个月前行异基因造血干细胞移植术。Auspitz's阳性。组织病理同时具备银屑病样和界面皮炎样改变。免疫组化CD4+T细胞、CD8+T淋巴细胞浸润。诊断:银屑病样移植物抗宿主病。外用0.1%他克莫司软膏治疗1周后,皮损明显消退。

A rare case of psoriasiform graft-versus-host disease is reported.The patient suffered from acute B-cell leukemia for more than 1 year.Nine months after allogenic hematopoietic stem cell transplantation,the patient developed red papules and plaques,with Auspitz sign positive and silver-white scales on the head,face,limb and trunk.The histopathology showed both psoriatic and interfacial dermatitis.Immunohistochemical staining demonstrated infiltration of CD4+and CD8+T cells.Diagnosis was psoriasiform graft-versus-host disease.Lesions were improved by topical 0.1%tacrolimus ointment.