间充质干细胞治疗结核分枝杆菌感染的基础研究进展

Update of mesenchymal stem cells in the treatment of Mycobacterium tuberculosis infection

间充质干细胞(MSCs)是一群具有高度自我更新能力和多向分化潜能的多能干细胞,已有多项研究证明其对结核分枝杆菌感染的治疗潜力。MSCs可通过抗菌肽与关键酶的分泌、细胞表面受体的表达,直接或间接地介导受宿主细胞由免疫抑制状态向激活状态转化,进而作为细胞治疗的一种手段,在足量抗菌药物覆盖的基础上,辅助杀灭以结核分枝杆菌为主的分枝杆菌感染,并抑制过度的炎症反应,减少不必要的组织损伤。本文就间充质干细胞治疗结核分枝杆菌感染的基础及临床前研究进展作一概述。

Mesenchymal stem cells(MSCs)are a group of pluripotent stem cells with high self-renewal ability and multi-directional differentiation potential.Substantial studies have proved their therapeutic potential for mycobacterium tuberculosis infection by promoting the secretion of antimicrobial peptides and key enzymes,and by expression of specific receptors on cell surface,and MSCs directly or indirectly mediate the transformation from the inhibited immune status to the activated one.On the basis of providing sufficient antibiotics,mesenchymal stem cells,serving as an approach of cell therapies,play an auxiliary role in the diseases caused by Mycobacterium tuberculosis.In the meanwhile,MSCs can inhibit excessive inflammation and reduce unnecessary tissue damages.The update of mesenchymal stem cells in the treatment of Mycobacterium tuberculosis infection is summarized in this paper.