靶向肠道菌群清除硫酸吲哚酚的研究现状

Research status of clearing indoxyl sulfate by targeting intestinal flora

硫酸吲哚酚(indoxyl sulfate,IS)作为一种典型的经肠道微生物代谢的尿毒症毒素,在慢性肾脏病(chronic kidney disease,CKD)及其相关并发症的发生、发展中起到重要作用。随着“肠肾轴”理论的提出,表明CKD患者在发生肠道菌群失调的同时,也会导致IS水平的升高,进一步加快CKD的进程,预后不佳。本文就近几年通过靶向肠道菌群清除IS的方法作一综述。

Indoxyl sulfate(IS),as a typical uremia toxin metabolized by intestinal microorganism,plays an important role in the occurrence and development of chronic kidney disease(CKD)and its related complications.With the proposal of"entero-renal axis"theory,it has shown that intestinal flora imbalance may elevate the level of IS level,accelerate disease progression and lead to a poor prognosis in CKD patients.This review summarized the latest methods of targeting intestinal flora for clearing IS.