脂质纳米圆盘作为药物递送系统的研究进展

Advances on Development of Lipid Nanodiscs as a Drug Delivery System

随着临床需求的增长和纳米技术的进步,纳米药物递送系统的研究日益深入。脂质纳米圆盘作为一种新兴的纳米药物递送系统,具有生物相容性好、药物负载能力高、长循环等优势,已被应用于抗肿瘤药、抗菌药的靶向递送研究。本研究介绍了脂质纳米圆盘的结构特点、优势及其分类与应用,并总结了目前研究中待解决的问题,以期为此类制剂的研究和改良提供思路。

With the increase of clinical demand and the improvement of nanotechnology,researches on nano-drug delivery systems(NDDS)have become increasingly in-depth.As a new type of NDDS,lipid nanodiscs(LND)show the advantages of desirable biocompatibility,high drug loading capacity,and the ability of long circulation,which can be used in the targeted delivery of antineoplastic and antibacterial drugs.This review summarizes the structural characteristics,superiority,classification,and applications of LND.Furthermore,the advantages and challenges are discussed,thereby providing approaches for promoting the formulation improvement of such preparations.