吸入制剂雾化技术概述

An Overview of Nebulization Techniques for Inhalation Preparations

吸入制剂属药械组合产品,需要制剂、装置和患者三方互相配合才能获得理想的疗效。常见的吸入给药装置局限于各自所采用的雾化技术,存在使用技巧要求高、药物利用率低、雾化时间长等问题。近年来为解决这些问题,研究者不但在传统吸入给药装置的触发机制、喷雾过程和雾化动力方面提出并尝试了多种新技术,还研发了振动筛雾化吸入器、软雾吸入器、热蒸发雾化吸入器和电流体动力雾化吸入器等新型雾化装置。本研究综述了这些传统和新型吸入器所采用的雾化技术,为未来吸入制剂雾化装置的研究提供参考。

Inhaled drugs are drug-device combination products,which require the cooperation of preparations,devices and patients to achieve desired treatment outcome.Common inhalation devices have problems such as difficult operation skill requirements,low drug availability,and long nebulization time due to their nebulization mechanisms.In terms of these issues,several novel techniques and inhalers are put forward in recent years,such as vibration mesh,soft mist,thermal evaporation atomization,and electrohydrodynamic atomization.Fundamental theory of traditional inhalers and these novel techniques are reviewed in this paper,aiming to provide some inspirations for future inhaler development.