脑靶向脂质体的研究进展

Research Advances on Brain-targeted Liposomes

中枢神经系统疾病是显著影响人类健康和生活质量的重大疾病之一。由于多数药物难以跨越血脑屏障(blood-brain barrier,BBB),使脑内局部浓度较低,无法充分发挥疗效。具有特殊表面修饰的脂质体能够作为脑靶向药物递送载体,将药物有效递送入脑。本研究对近年来脑靶向脂质体的生物特性、通过BBB的机制、经鼻-脑靶向给药的应用进行综述,以期为药物脑靶向递送策略提供新思路。

Central nervous system disease is one of the major diseases that significantly affect human health and quality of life.Most drugs cannot cross the blood-brain barrier(BBB),so that their concentrations are too low to completely produce therapeutic effects.Liposomes with special surface modifications can be used as brain-targeted drug carriers to effectively deliver drugs to the brain.This review summarizes the biological properties,BBB crossing mechanisms,and the application of nose-to-brain delivery of brain-targeted liposomes to provide new ideas for drug brain targeting strategies.