能谱CT评估肺动脉高压临床应用状况

Status in clinical application of energy spectrum CT in evaluating pulmonary hypertension

肺动脉高压是指由多种异源性疾病(病因)和不同发病机制所致肺血管结构或功能改变,引起肺血管阻力和肺动脉压力升高的临床和病理生理综合征,继而可发展成右心衰竭甚至死亡。肺动脉高压病因复杂,可来源于肺血管的自身病变,也可继发于心肺疾病或系统性疾病,其预后取决于不同的病因。根据临床表现、病理发现、血流动力学特征和治疗策略可将肺动脉高压分为5类,不同类型的肺动脉高压需要不同的药物干预。能谱计算机体层摄影(CT)相比传统CT最大的优势在于同时获得心肺解剖结构、血流灌注和肺通气情况的信息,减少伪影的产生,有效增加诊断的准确性。本研究旨在探讨新型成像工具能谱CT评估肺动脉高压分类并指导药物选择的价值。

Pulmonary hypertension is a clinical and pathophysiological syndrome caused by changes in pulmonary vascular structure or function caused by various allogenic diseases(etiologies)and different pathogenesis,resulting in pulmonary vascular resistance and increased pulmonary arterial pressure,which can then develop into right heart failure or even death.The etiology of pulmonary hypertension is complex,which can be caused by auto pathological changes of pulmonary vessels,cardiopulmonary diseases or systemic diseases.According to clinical manifestations,pathological findings,hemodynamic characteristics and treatment strategies,pulmonary hypertension can be divided into five categories.Different types of pulmonary hypertension require different drug intervention.Compared with traditional computer tomography(CT),energy spectrum CT has the greatest advantage of simultaneously obtaining the information of cardiopulmonary anatomical structure,blood perfusion and lung ventilation,reducing the generation of artifacts and effectively increasing the accuracy of diagnosis.The purpose of this study was to evaluate the value of a novel imaging tool,energy spectrum CT,in evaluating the classification of pulmonary hypertension and guiding drug selection.