血清幽门螺杆菌抗体和可溶性淋巴细胞活化基因-3表达水平对早期胃癌的诊断价值

Diagnostic value of serum Helicobacter pylori antibody and soluble lymphocyte activation gene-3 expression in early gastric cancer

探讨血清幽门螺杆菌(Hp)抗体和可溶性淋巴细胞活化基因-3(sLAG-3)用于早期胃癌诊断的临床应用价值。结果发现胃癌、胃良性病变及健康对照组血清Hp抗体阳性率、sLAG-3、癌胚抗原(CEA)、胃蛋白酶原比值(PGR)差异具有统计学意义, 且其表达与早期胃癌分化程度相关(P<0.05)。经ROC曲线分析, 血清Hp抗体联合sLAG-3诊断早期胃癌具有较高临床应用价值。

The purpose of this study is to investigate the clinical value of serum Helicobacter pylori(Hp)antibody and soluble lymphocyte activation gene-3(sLAG-3)in diagnosing early gastric cancer.The findings of this study showed significant differences in Hp antibody positivity,sLAG-3 expression,carcinoembryonic antigen(CEA),and pepsinogen ratio(PGR)in serum across patients with gastric cancer,benign gastric lesions and healthy controls.In addition,these indices were correlated with the differentiation of early gastric cancer(P<0.05).ROC curve analysis showed that serum Hp antibody combined with sLAG-3 expression is fairly useful in clinical diagnosis of early gastric cancer.