摘要
BACKGROUND Inflammatory bowel disease(IBD)can lead to social and economic impacts worldwide.In Brazil,where its adult prevalence is increasing,the epidemiology of the pediatric population is not well known,although there is a documented increase in pediatric IBD incidence worldwide.Brazil has continental dimensions,and Espírito Santo is a state of southeastern Brazil,the region with the highest demographic densities and is the economically most important in the country.AIM To assess the prevalence,incidence,phenotype and medications in a Southeastern Brazilian pediatric population.METHODS Data were retrieved from the Public Medication-Dispensing System of the Department of Health in Espírito Santo state from documentation required to have access to highly expensive medication from August 1,2012 to July 31,2014.There were 1048 registered patients with IBD of all ages,and of these patients,the cases≤17 years were selected.The data were obtained through the analysis of administrative requests for these medications and included medical reports,endoscopy exams,histopathology and imaging tests,which followed the Clinical Protocols and Therapeutic Guidelines of the Brazilian Government.Only confirmed cases of IBD were included in the study.RESULTS There were 55 pediatric patients/1048 registered patients(5.34%),with Crohn's disease(CD)representing 30/55(55%),ulcerative colitis(UC)24/55(43.6%)and 1 unclassified IBD,a significant difference from adult patients(P=0.004).The prevalence of IBD in pediatric patients was 5.02 cases/100.000 inhabitants;the incidence in 2014 was 1.36 cases/100.000 inhabitants.The mean age at diagnosis was 12.2 years(±4.2).There were 7 children diagnosed up to 6 years old,7 between 7 to 10 years old and 41 between 11 and≤17 years old.There was no difference in the distribution of UC and CD between these age categories(P=0.743).There was no difference in gender distribution in relation to adults.Children and adolescents with UC had a predominance of pancolitis,unlike adults(P=0.001),and used aminosalicylates and immunomodulators for their treatment.Pediatric patients with CD did not present a difference in disease location but had a higher frequency of fistulizing behavior(P=0.03)and perianal disease phenotype(P=0.007)than adult patients.Patients with CD used more immunomodulators and biological therapy.Treatment with biological therapy was more frequently used in pediatric patients than in adults(P<0.001).CONCLUSION Although the data from this study demonstrate that incidence and prevalence rates are low in southeastern Brazil,these data demonstrate the severity of IBD in pediatric patients,with the need for early diagnosis and therapy,avoiding serious damage.
基金
approved by the Ethics and Research Committee of the Nossa Senhora da Gloria Children’s Hospital(CAAE 19602813.8.0000.5069)after obtaining authorization from the State Office for Pharmaceutical Assistance.The term of clarification and consent was waived because the data used is secondary data.
