检测DCB为重氮组分的有机颜料还原其致癌性

DCB testing for carcinogenicity detection of organic pigment with diazo group

1994年7月15日,德国联邦政府颁布了《食品及日用品消费品法》(LFGB)第二修正案,法案禁止使用可以通过一个或多个偶氮基分解形成MAK(Ⅲ)A1或A2组芳胺类,总计20种芳胺,其中包括3,3’-二氯联苯胺(DCB),加上欧共体EU67/1548附录C2级两个芳香胺以及STANDARD 100 by OEKO-TEX增加两个,共24个涉嫌致癌芳胺(包括我国在内的各国法规都是这些芳香胺)。但1994年后所使用的检测方法无法检出以DCB为中间体的有机颜料,因为以DCB为中间体的有机颜料在1996年7月23日颁布的第五修正案的法定分析条件下不会断裂分解,因此其使用不受限制。直到2002年11月欧盟出台了欧洲标准EN 14361-2:2003,使用萃取样品预处理方法,使其还原分解出DCB,才能执行法案禁用以DCB为中间体的有机颜料。

The Second Amendment to Lebensmittelund Futtermittelgesetzbuch(LFGB)was promulgated by German federal government on July 15,1994.The law prohibited the use of what can be degraded to 20 aryamines in MAK(Ⅲ)A1or A2 by one or more azo-based groups,including the 3,3’-dichloropaniline(DCB).Additionally,there are two arylamines from European Communities EU67/1548 Appendix C2 and two arylamines from STANDARD 100 by OEKO-TEX.A total of 24 suspected carcinogenic arylamines were determined by the laws and regulations of China and other countries.However,the organic pigments using DCB as the intermediate cannot be detected by the test method after 1994,leading to unlimited usage.Because those pigments cannot be broken and decomposed at the legal analysis conditions of the Fifth Amendment enacted on July 23,1996.The pretreatment method of extraction samples was used to decompose the pigments until the EU introduced the European Standard EN 14361-2:2003.DCB can be obtained from the reductive decomposition of the organic pigments using DCB as the intermediate,resulting in the prohibition of those pigments by LFGB law.