多感官刺激联合吡格列酮对老年阿尔茨海默病伴2型糖尿病的作用研究

Effects of multi-sensory stimulation combined with pioglitazone on elderly alzheimer’s disease with type 2 diabetes mellitus

文章探讨了在老年阿尔茨海默病伴2型糖尿病患者中多感官刺激联合吡格列酮的治疗作用。将140例老年阿尔茨海默病伴2型糖尿病患者作为受试者,随机数表分为对照组、刺激组、药物组、联合组,均给予常规治疗;刺激组给予多感官刺激,药物组给予吡格列酮,联合组给予多感官刺激联合吡格列酮,比较各组治疗前后的血糖指标、精神状态、临床疗效和药物安全性等。结果显示:治疗后各组智能、精神状态评分均升高(P<0.05),日常生活能力评分均下降(P<0.05);治疗后4组上述评分、对阿尔茨海默病的疗效、总有效率对比差异均有统计学意义(P<0.05),治疗后每2组间评分和总有效率对比,联合组智能与精神状态评分和总有效率>刺激组/药物组>对照组,联合组日常生活能力评分<刺激组/药物组<对照组(P<0.05);治疗后各组FPG、2h PG、HbA1c、对2型糖尿病的疗效和总有效率对比差异均有统计学意义(P<0.05),血糖指标水平均较本组治疗前显著下降(P<0.05),且治疗后联合组血糖指标、总有效率与药物组均相近(P>0.05),刺激组血糖指标、总有效率与对照组均相近(P>0.05),而联合组、药物组血糖指标均高于刺激组、对照组(P<0.05),前者总有效率也均高于后者(P<0.01);各组不良反应发生率对比差异无统计学意义(P>0.05)。对老年阿尔茨海默病伴2型糖尿病患者在常规治疗的基础上给予多感官刺激联合吡格列酮可改善其智能、精神状态及日常生活能力,理想控制血糖指标,疗效理想且安全可靠。

This article discusses the therapeutic effect of multi-sensory stimulation combined with pioglitazone in elderly patients with Alzheimer’s disease with type 2 diabetes.140 elderly patients with Alzheimer’s disease with type 2 diabetes were treated as subjects.The random number table was divided into control group,stimulation group,drug group,combination group,and gave conventional therapy,stimulation group gave multi-sensory stimulation,drug group gave pioglitazone,combination group gave multi-sensory stimulation combined with pioglitazone.Compare the blood glucose indicators,mental status,clinical efficacy and drug safety before and after each group of treatment.The results showed that intelligence and mental state scores increased in each group after treatment(P<0.05).The daily living ability scores all decreased(P<0.05).After treatment,the above scores,efficacy and total efficiency were statistically significant(P<0.05).Compare the scoring and total efficiency between each two groups after treatment,the combination group intelligence and mental state score and total efficiency>stimulation/drug group>control group,the combined group had a daily living ability score<stimulus group/drug group<control group(P<0.05);FPG,2h PG,HbA1c,and overall efficiency and efficacy for type 2 diabetes were significantly different(P<0.05).The level of blood glucose index all decreased significantly compared with that before treatment in this group(P<0.05).After treatment,the blood glucose index and total efficiency of the combined group were similar to the drug group(P>0.05).The blood glucose index and total efficiency of the stimulation group were similar to the control group(P>0.05).However,the blood glucose indexes of the combination and drug groups were higher than those of the stimulation and control groups(P<0.05).The total efficiency of the former is also higher than that of the latter(P<0.01);there was no significant difference in the incidence of adverse effects in each group(P>0.05).Multi-sensory stimulation and pioglitazone in elderly patients with type 2 diabetes can improve their intelligence,mental state and daily living ability,control blood glucose index,and have ideal efficacy and safe and reliable effect.