二甲双胍通过调控糖代谢抑制甲状腺结节的研究进展

Progress in the study of metformin inhibiting thyroid nodules by regulating glucose metabolism

甲状腺结节是指各种原因导致甲状腺内出现的一个或多个组织结构异常的团块。近年来甲状腺结节患病率不断增加,糖代谢异常可能是其重要原因之一,主要涉及胰岛素/胰岛素样生长因子1、瘦素、炎症、遗传免疫等机制。二甲双胍作内应用最广泛的抗糖尿病药物,可以通过不同信号通路发挥抑制甲状腺结节的作用。文章就此方面研究进展进行综述。

The prevalence of thyroid nodules has been increasing in recent years,and some studies have shown that glucose metabolic disorder may be one of the important reasons,mainly involving insulin/insulin-like growth factor 1,leptin,inflammation,genetic immunity and other mechanisms.Metformin can inhibit thyroid nodules through different signaling pathways.This article introduces the linkage between thyroid nodules and glucose metabolism disorders,and analyzes the mechanism of metformin inhibiting thyroid nodules.