肺癌合并肺结核的机制研究及诊治进展

Advances in the pathogenesis,diagnosis and treatment of lung cancer with pulmonary tuberculosis

肺癌及肺结核是呼吸系统的常见病,两者在发病机制上存在许多相关性。肺结核导致的瘢痕、慢性炎症、免疫功能异常可增加肺癌风险。肺癌的肿瘤微环境处于免疫抑制状态,利于结核分枝杆菌免疫逃逸。肺癌的免疫治疗也可影响结核发展。如何早期识别肺癌合并结核、选择合适的治疗方法是目前的诊疗难点。了解肺癌合并肺结核的发病机制有助于寻找新的诊治方法。文章重点就肺癌合并结核的发病机制、诊疗策略进行综述,以对其进行早期诊断、精准治疗。

Lungcancer and pulmonary tuberculosis are two common diseases in respiratory system,which are correlated in pathogenesis.Scars,chronic inflammation and abnormal immunity in lung induced by tuberculosis increase the risk of lung cancer.The immunosuppressive status in lung cancer tumor microenvironment enhances immune evasion of Mycobacterium tuberculosis.Additionally,immunotherapy in lung cancer in fluences the development of tuberculous.Therefore,the main challenge in clinic practice is early diagnosis and therapeutics for lung cancer with pulmonary tuberculosis.Understanding the pathogenesis of lung cancer with pulmonary tuberculosis is helpful to develop new diagnostic and therapeutical methods.This article summarizes the pathogenesis,diagnosis and treatment of lung cancer with pulmonary tuberculosis for itsearly diagnosis and precision therapy.