富含亮氨酸重复序列激酶2调控自噬影响甲状腺癌可能机制的研究进展

Progress of the possible mechanism of leucine-rich repeat kinase 2 affecting thyroid cancer via regulating autophagy

甲状腺癌是内分泌系统最常见的恶性肿瘤,且发病率逐年上升,严重威胁人们的身体健康。自噬是一种程序性死亡方式,能够作为抗肿瘤治疗潜在的作用靶点,发挥重要的调控作用。富含亮氨酸重复序列激酶2(LRRK2)是由PARK8基因编码的一种蛋白激酶。最近研究证实,细胞自噬和甲状腺癌关系密切。文章就LRRK2通过自噬影响甲状腺癌的可能调控机制进行分析,为甲状腺癌的基础研究和临床诊疗提供新思路。

Thyroid cancer is the most common malignant tumor of the endocrine system,and the incidence is increasing year by year,which seriously threatens people's health.Autophagy is a programmed mode of death that can be used as a potential target for anti-tumor therapy and plays an important regulatory role.Leucine-rich repeat kinase 2(LRRK2)is a protein kinase encoded by PARK8 gene.The recent studies have confirmed that autophagy is closely related to thyroid cancer.This paper analyzes the possible regulatory mechanism of LRRK2 affecting thyroid cancer through autophagy,providing new ideas for basic research and clinical diagnosis and treatment of thyroid cancer.