β淀粉样蛋白在缺氧/缺血性脑损伤中的作用研究

Role ofβ-amyloid protein in hypoxic/ischemic brain injury

β淀粉样蛋白(Aβ)由β淀粉样前体蛋白在β-分泌酶和γ-分泌酶作用下产生。Aβ积累和聚集,形成寡聚体和纤维,并在大脑中沉积,导致功能性神经元死亡、认知损伤。Aβ诱导炎性反应、氧化应激、自由基损伤、钙离子紊乱等造成神经细胞的坏死和凋亡。近期研究发现Aβ在缺氧/缺血性脑损伤中也发挥重要作用。本文综述Aβ在缺氧/缺血性脑损伤中的作用机制。

β-amyloid protein(Aβ)is produced fromβ-amyloid precursor protein under the action ofβ-secretase andγ-secretase.Aβaccumulates and aggregates,forms oligomers and fibrils,and deposits in the brain,leading to functional neuronal death and cognitive impairment.β-amyloid protein induces inflammatory response,oxidative stress,free radical damage,calciumion disorder and so on,resulting in neuronal necrosis and apoptosis.Recent studies show thatβ-amyloid also plays an important role in hypoxia/ischemic brain injury.We review the mechanism ofβ-amyloid protein in hypoxic/ischemic brain injury.