内质网氨基肽酶1的单核苷酸多态性(rs17482078)与白塞综合征风险的meta分析

Endoplasmic reticulum aminopeptidase 1 SNPs (rs17482078) and the risk of Behcet’s Syndrome: A meta-analysis

目的 综合评价内质网氨基肽酶1(ERAP1)基因单核苷酸多态性与白塞综合征的相关性,为今后白塞综合征高危人群的筛选与预防提供依据。方法 通过PubMed、Embase、Web of Science以及知网和万方数据库检索2021年12月前符合条件的文献,运用优势比(OR)及其95%可信区间(95%CI)来评价关联强度。采用显性模型、隐性模型和超显性模型评价ERAP1基因单核苷酸多态性与白塞综合征的关联。结果 共纳入5篇文献,包含4 980个样本(2 394名病例和2586名对照)。结果显示,ERAP1基因单核苷氨酸多态性rs17482078位点与普通人群白塞综合征易感性相关(C等位基因OR:0.75,95%CI:0.60-0.95;隐性模型OR:2.95,95%CI:2.08-4.18)。亚组分析显示,多态性rs17482078位点的C等位基因在中东地区人群中(OR:0.86,95%CI:0.76-0.98)降低了白塞综合征的患病风险。结论 ERAP1基因单核苷酸多态性rs17482078是白塞综合征发病风险的重要遗传因素,且其在不同种族间的遗传关联性不同。

Objective To comprehensively evaluate the correlation between gene single nucleotide polymorphism of endoplasmic reticulum aminopeptidase 1(ERAP1) and Behcet’s syndrome, and provide a basis for the screening and prevention of high-risk groups of Beh?et’s syndrome in the future. Methods PubMed,Embase,Web of Science, CNKI, and Wanfang databases were used to search the eligible articles before December 2021.The odds ratio(OR) and its 95% confidence intervals(95% CI) were used to evaluate the strength of the association. Dominance model, recessive model,and overdominance model were used to evaluate the association between ERAP1 gene SNPs and Behcet’s syndrome. Results A total of 5studies contained 4 980 samples(2 394 cases and 2 586 controls) were eligible for this meta-analysis.The results showed that the single nucleotide polymorphism rs17482078 of the ERAP1 gene was associated with the susceptibility of Behcet’s syndrome in the general population(C allele OR: 0.75,95% CI: 0.60-0.95;recessive model OR: 2.95,95% CI: 2.08-4.18).Subgroup analysis showed that C allele of the polymorphism rs17482078 reduced the risk of Behcet’s syndrome in the Middle Eastern population (OR: 0.86,95% CI: 0.76-0.98).Conclusion The single nucleotide polymorphism of ERAP1 gene rs17482078is an important genetic factor for the increased risk of Behcet’s syndrome,and the genetic association is different among different ethnic groups.