粪菌移植治疗腹泻型肠易激综合征研究进展

Research Progress in Fecal Microbiota Transplantation for Diarrhea-Predominant Irritable Bowel Syndrome

肠易激综合征(IBS)是一种病因和发病机制未明的慢性功能性胃肠病,以腹痛、腹胀伴排便习惯及性状改变为主要症状。我国以腹泻型肠易激亚型(IBS-D)最常见。IBS的发生被证实与肠道菌群失衡密切相关。粪菌移植(FMT)指将供体粪便中的功能菌群移植到患者胃肠道,改善肠道菌群,重建正常肠道微生态,进而改善临床症状。目前,关于粪菌移植治疗腹泻型肠易激综合征的研究越来越多,并取得一定临床疗效。文章就肠道菌群与IBS-D的关系及IBS-D粪菌移植治疗的治疗作用、安全性等最新研究进展进行综述。

Irritable bowel syndrome(IBS),a chronic functional gastrointestinal disease with unknown etiology and pathogenesis,is characterized by abdominal pain and abdominal distension with changes in bowel habits and stool characteristics.Diarrhea-predominant irritable bowel syndrome(IBS-D)is the most common type of IBS in China.The occurrence of IBS has been proved to be closely related to the imbalance of intestinal flora.Fecal microbiota transplantation(FMT)refers to the transfer of functional microflora from donor’s feces into patient’s gastrointestinal tract to improve intestinal flora,reconstruct normal intestinal microecology and ameliorate clinical symptoms.At present,more and more studies focus on the treatment of IBS-D with FMT,and some clinical effects have been achieved.This paper reviews the relationship between intestinal flora and IBS-D and the efficacy and safety of FMT for IBS-D.