NB-UVB治疗白癜风疗效的影响因素研究

Study on the influencing factors of the therapeutic effect of NB-UVB on vitiligo

目的探讨窄谱中波紫外线(NB-UVB)治疗白癜风疗效的影响因素。方法选择2019年1月—2021年9月本院收治的白癜风患者200例作为研究对象,其中采用NB-UVB治疗的100例患者作为实验组,采用他克莫司软膏治疗的100例患者作为对照组。比较两组临床疗效,根据NB-UVB治疗效果分成有效组和无效组两组,比较两组临床特征,分析影响其疗效的单因素,包括性别、发病年龄、发病部位、病程、类型、临床分期、病因、白发症、白斑形态、照射次数、累计治疗剂量,将有差异的因素纳入Logistic回归模型,分析影响NB-UVB疗效的多因素。结果实验组总有效率为75.00%,显著高于对照组的54.00%(P<0.05)。无效组发病年龄≥20岁、发病位于手足处、病程≥24个月、进展期、白发症、白斑形态不规则占比分别为48.00%、40.00%、68.00%、80.00%、48.00%、60.00%,显著高于有效组的14.67%、10.67%、41.33%、57.33%、12.00%、28.00%(P<0.05)。Logistic回归性分析提示发病年龄≥20岁、发病位于手足处、病程≥24个月、进展期、白发症、白斑形态不规则是影响NB-UVB疗效的因素(P<0.05)。结论与常规药物治疗相比,NB-UVB能提高白癜风的治疗效果,且NB-UVB疗效主要与发病年龄、发病部位、病程、临床分期、白发症、白斑形态有关。

Objective To explore the influence factors of narrow band ultraviolet B(NB-UVB)in the treatment of vitiligo.Methods From January 2019 to September 2021,200 patients suffered with vitiligo,those were admitted to our hospital,were selected as study objects.Among them,the 100 patients treated with NBUVB were enrolled in the experimental group and the 100 patients treated with tacrolimus ointment were included into the control group.The clinical characteristics of the two groups were compared.According to the effect of NBUVB,the patients in the experimental group were divided into the effective group and the ineffective group,the clinical efficacy of the two groups were compared.The single factors affecting the effect were analyzed,including gender,age of onset,location of onset,course,type,clinical stage,etiology,poliosis,leukoplakia shape,irradiation times and cumulative treatment dose.The factors presented statistical significance were included in the logistic regression model to analyze the multiple factors affecting the efficacy of NB-UVB.Results The total effective rate of the experimental group was 75.00%,which was significantly higher than 54.00%of the control group(P<0.05).The the proportion of the following factors in the ineffective group:age over or equal to 20 years old,disease onset in hands and feet,course over or equal to 24 months,progressive stage,poliosis and irregular white spot were 48.00%,40.00%,68.00%,80.00%,48.00%and 60.00%,respectively,and those were significantly higher than 14.67%,10.67%,41.33%,57.33%,12.00%and 28.00%in the effective group(P<0.05).Logistic regression analysis showed that the age of onset over or equal to 20 years old,onset at hand and foot,course of disease over or equal to 24 months,progressive stage,poliosis,irregular leukoplakia morphology were the factors affecting the efficacy of NB-UVB(P<0.05).Conclusions Compared with the conventional drug treatment,NB-UVB could improve the therapeutic effect of vitiligo,and the therapeutic effect of NB-UVB is mainly related to the age of onset,the site of onset,the course of disease,clinical stage,poliosis,and the shape of leukoplakia.