不同性别不稳定型心绞痛患者发病危险因素差异分析

Study on differences of homocysteine,uric acid and brain natriuretic peptide in patients with unstable angina pectoris of different genders

目的:探讨不同性别不稳定型心绞痛(UAP)患者同型半胱氨酸(Hcy)、尿酸(UA)及脑钠肽(BNP)的差异及其与UAP发病的相关性。方法:选取某院心血管内科住院治疗的UAP患者126例作为观察组,另选取同期冠状动脉造影检查正常的非冠心病(CHD)患者68例作为对照组,比较2组受试者一般资料和Hcy、UA及BNP水平差异,采用Logistic回归分析影响不同性别UAP患者发病的因素。结果:高血压病史、LDL-C、Hcy、UA水平在男性观察组与男性对照组间比较,差异有统计学意义(P<0.05);女性观察组与女性对照组间FPG、LDL-C、Hcy及N末端B型利钠肽(NT-proBNP)水平比较,差异有统计学意义(P<0.05)。观察组男性Hcy、UA水平高于女性,而NT-proBNP低于女性,差异有统计学意义(P<0.05)。Logistic回归分析结果显示:高血压病史和Hcy、UA、LDL-C高水平为男性UAP患者发病的独立危险因素;而NT-proBNP、Hcy、FGP、LDL-C高水平为女性UAP患者发病的独立危险因素。结论:不同性别人群影响UAP发生的因素不同,高血压病史和Hcy、UA、LDL-C高水平可增加男性患者UAP发生风险,NT-proBNP、Hcy、FGP、LDL-C高水平可增加女性患者UAP发生风险。

Objective:To investigate the differences of homocysteine(Hcy),uric acid(UA)and brain natriuretic peptide(BNP)in patients with unstable angina pectoris(UAP)of different genders and their correlation with pathogenesis of UAP.Methods:A total of 126 UAP patients hospitalized in a hospital were selected as the observation group,and another 68 patients with non-coronary heart disease with normal coronary angiography during the same period were selected as the control group.General data and differences in Hcy,UA and BNP between the two groups of different genders were compared.Results:History of hypertension,LDL-C,Hcy and UA indexes were compared between the male observation group and the male control group,and the differences were statistically significant(P<0.05).In comparison of FPG,LDL-C,Hcy and NT-proBNP levels between the female observation group and the female control group,the differences were statistically significant(P<0.05).In the observation group,the levels of Hcy and UA in males were higher than those in females,while the levels of NT-proBNP were lower than those in females,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that history of hypertension and high levels of Hcy,UA,and LDL-C were independent risk factors for UAP in males;while high levels of NT-proBNP,Hcy,FGP,and LDL-C were independent risk factors for UAP in females.Conclusion:Different gender populations have different factors affecting the occurrence of UAP.History of hypertension and high levels of Hcy,UA,and LDL-C can increase the risk of UAP in men,while high levels of NT-proBNP,Hcy,FGP,and LDL-C can increase the risk of UAP in women.