基于数据挖掘分析中成药治疗慢性支气管炎的用药规律

Analysis on the rules of Chinese patent medicines in treating chronic bronchitis based on data mining

目的:探究中成药治疗慢性支气管炎的用药特点及组方规律。方法:遴选并整理《中国药典》《中华人民共和国卫生部药品标准·中药成方制剂》《国家中成药标准汇编》《新编国家中成药》和《新药转正标准》收录的治疗慢性支气管炎的中成药处方,对其组方用药规律进行分析。结果:纳入处方99首,涵盖18个证候,涉及中药206味,功效分类以化痰止咳平喘、补虚、清热等为主;药性偏温、寒、平,药味偏苦、辛、甘,主归肺、脾、心经;关联规则得到核心药对组合11个;系统聚类分析归为7类;通过复杂网络分析发现其核心药物为甘草、麻黄、葶苈子等。结论:中成药治疗慢性支气管炎用药重视清、宣、润功效的结合,具有“宣清合法”“清中有润”“气阴兼顾”等组方特点。

OBJECTIVE To explore the characteristics and prescription rules of Chinese patent medicines in treating chronic bronchitis(CB).METHODS The prescriptions of Chinese patent medicines for CB included in the Chinese Pharmacopoeia, Composition Principles of Chinese Patent Drugs, Compilation of National Standard for Traditional Chinese Medicines, Newly Edited National Chinese Traditional Patent Medicines and New Drug Conversion Standard were selected and sorted out, and their prescription regularity were analyzed.RESULTS A total of 99 prescriptions were included, covering 18 syndromes and involving 206 traditional Chinese medicines. Their efficacy classification was mainly about relieving phlegm, cough and asthma, tonifying deficiency, clearing heat and so on. Their drug natures were warm, cold and flat, and the tastes were bitter, spicy and sweet, which were mainly for lung, spleen and heart meridian. Eleven core drug pair combinations were obtained by association rules. The systematic clustering analysis divided them into 7 categories. Through complex network analysis, the core drugs included Glycyrrhizae Radix et Rhizoma, Ephedrae Herba, Descurainiae Semen Lepidii, etc.CONCLUSION In the treatment of chronic bronchitis, Chinese patent medicine attaches great importance to the combination of clearing, ventilating and moistening effects with the prescription characteristics of “clearing and ventilating legitimate”, “clearing with moistening” and “qi and yin taking into account”.