可诱导组织再生骨植入材料的研究进展

Research progress of bone implant materials with inducible tissue regeneration

第三代骨修复和植入材料除了要满足生物相容性、力学相容性等要求,同时还要求具备骨传导、骨诱导和可控降解等特性,以实现骨组织的诱导再生。笔者通过梳理相关文献,从骨植入材料的分类、生物相容性、力学特性、拓扑结构、可控降解、组织诱导再生、加工制备及表面处理等方面对近年来可诱导组织再生骨植入材料的研究现状及最新动态进行了阐述,提出可控金属增材制造技术可能是未来骨植入材料加工制备的重要发展方向;将活性陶瓷与多孔钛基体高质量结合,在保证力学性能的基础上对骨植入体进行降解速率调控,将是实现骨植入材料组织诱导再生的关键。

The third generation bone repair and implant materials not only meet the requirements of biocompatibility and mechanical compatibility,but also have the characteristics of bone conduction,bone induction and controllable degradation,so as to realize the induced regeneration of bone tissue.In this paper,the research status and latest trends of bone implant materials with induced tissue regeneration in recent years are described and prospected from the aspects of classification,biocompatibility,mechanical properties,topology,controllable degradation,tissue induced regeneration,processing and surface treatment,It is suggested that the controllable metal additive manufacturing technology may be an important development direction for the processing and preparation of bone implant materials in the future;The combination of active ceramics and porous titanium matrix with high quality,and the control of degradation rate of bone implants on the basis of guaranteeing mechanical properties will be the key to achieving tissue induced regeneration of bone implant materials.