丙泊酚与七氟烷麻醉对根治性胃切除手术患者术后疼痛的影响

Effects of propofol and sevoflurane anesthesia on postoperative pain in patients undergoing radical gastrectomy

目的 探讨对根治性胃切除手术患者分别给予丙泊酚以及七氟烷麻醉后对术后疼痛产生的影响。方法 选取2018~2020年枣庄矿业集团中心医院收治的根治性胃切除手术患者58例进行麻醉干预研究,随机分为丙泊酚组(采用丙泊酚药物实施麻醉干预)和七氟烷组(采用七氟烷药物实施麻醉干预),每组各29例。比较两组患者拔管时间、手术时间、PACU时间、输入液体总量、术中芬太尼用量、尿量以及术后不同时间段疼痛评分。结果 两组拔管时间、手术时间、PACU时间、输入液体总量、术中芬太尼用量、尿量比较,差异无统计学意义(P>0.05);丙泊酚组术后1 h咳嗽NRS及休息NRS评分、术后2 h咳嗽NRS及休息NRS评分、术后8 h咳嗽NRS及休息NRS评分均低于七氟烷组,差异有统计学意义(P<0.05)。结论 丙泊酚麻醉药物有效应用,同七氟烷比较,在拔管时间、手术时间、PACU时间、输入液体总量、术中芬太尼用量、尿量等方面,无明显差异,但能够将术后不同时间段咳嗽以及休息状态下的疼痛状态有效改善,促进根治性胃切除手术患者预后水平显著提升。

Objective To investigate the effects of propofol and sevoflurane anesthesia on postoperative pain in patients undergoing radical gastrectomy. Methods A total of 58 patients undergoing radical gastrectomy admitted from2018 to 2020 were selected as subjects of the anesthetic intervention study. They were randomly divided into the propofol group(anesthetic intervention was performed with propofol) and the sevoflurane group(anesthetic intervention was performed with sevoflurane), with 29 patients in each group. The extubation time, operation time, length of stay in the postanesthesia care unit(PACU), total volume of fluid input, intraoperative fentanyl dosage, urine output, and postoperative pain scores at different periods were compared between the two groups. Results There were no statistically significant differences between the two groups in the extubation time, operation time, length of stay in PACU, total volume of fluid input, intraoperative fentanyl dosage and urine output(P>0.05). The Numeric Rating Scale(NRS) score during cough and resting at 1 h after surgery, the NRS score during cough and resting at 2 h after surgery, and the NRS score during cough and resting at 8 h after surgery in the propofol group were lower than those in the sevoflurane group, with statistically significant differences(P <0.05). Conclusion There are no significant differences between propofol and sevoflurane in terms of extubation time, operation time, length of stay in PACU, total volume of fluid input, intraoperative fentanyl dosage, and urine output. However, propofol can more effectively alleviate pain during coughing and resting in different postoperative periods and more significantly improve the prognosis of patients undergoing radical gastrectomy.