精神分裂症患者常见头颅CT表现及相关性研究

CT Findings and Correlation Study of Common Head in Patients with Schizophrenia

目的:对精神分裂症患者应用计算机体层成像(Computed Tomography,CT)检查技术,探析此技术的临床特征及相关性。方法:回顾性分析2019年1月~2020年2月收治的70例精神分裂症患者(观察组)及同期70例健康志愿者(对照组)的各脑叶CT值,采用阳性症状量表(SAPS)和阴性症状量表(SANS)进行评分比较,并对患者年龄、阴性症状评分与CT值间作相关性分析。结果:经CT检查后结果显示,精神分裂症患者各脑叶间CT值差异无统计学意义(P>0.05);与对照组相比,观察组各脑叶CT值与年龄、SAPS、SANS评分显著相关,差异明显有统计学意义(P<0.05);对患者发放明尼苏达多相人格调查表(MMPI)发现其评分均超过50,提示精神症状严重。结论:部分精神分裂症患者的脑结构异常与精神症状显著相关,且年龄与脑结构异常呈相关性,提示可将其归结与非遗传性,但仍需要大样本进行研究证实。

Objective:To explore the clinical characteristics and correlation of CT examination technique in patients with schizophrenia.Methods:The CT values of each cerebral lobe of 70 patients with schizophrenia(observation group)and 70 healthy volunteers(control group)admitted from January 2019 to February 2020 were retrospectively analyzed,and the positive symptom scale(SAPS)and Negative Symptoms Scale(SANS)were compared,and the correlation analysis was made between patients'age,negative symptom scores and CT values.Results:The results of CT showed that there was no significant difference in CT value between the lobes of schizophrenics(P>0.05);Compared with the control group,the CT values of the observation group were significantly correlated with age,SAPS and sans scores,and the difference was statistically significant(P<0.05);The MMPI scores of the patients were more than 50,indicating that the mental symptoms were serious.Conclusion:In some patients with schizophrenia,brain structural abnormalities are significantly correlated with mental symptoms,and age is correlated with brain structural abnormalities,suggesting that it can be attributed to non-heritable,but it still needs to be confirmed by large sample study.