纳米抗体在癌症治疗中的研究进展

Recent advances in nanobody based therapeutics in cancer

纳米抗体是一种单域抗体,具有体积小(~15 kDa)、稳定性好、易于加工和修饰、循环半衰期短、组织穿透性高、特异性和亲和力高等优点。因此,纳米抗体在疾病治疗研究中极具吸引力。癌症是严重危害人类健康的一类疾病,其治疗方法多种多样,其中靶向治疗逐渐成为癌症治疗的重要疗法之一。该文回顾并展望了纳米抗体结合不同技术平台在癌症靶向治疗领域的应用。

Nanobodies are single-domain antibodies, with many properties such as small size(~15 kDa), stability,ease of labeling and engineering for diverse formats, short circulatory half-life, high tissue penetration, high specificity, and high affinity. Therefore, it is very attractive in the research of disease treatment. Cancer is a kind of disease which seriously endangers human health. There are many treatments for cancer, among which targeted therapy has become one of the most important ttreatments in cancer treatment. This article reviews and prospects applications of nanobodies combined with different technology platforms in the field of cancer targeted therapy.