超声雾化吸入与氧气雾化吸入对慢性阻塞性肺疾病的应用效果分析

Effect analysis of ultrasonic atomization inhalation and oxygen atomization inhalation in patients with chronic obstructive pulmonary disease

目的 研究慢性阻塞性肺疾病患者应用超声雾化吸入与氧气雾化吸入的临床疗效。方法 91例慢性阻塞性肺疾病患者,随机分为A组(46例)和B组(45例)。A组采取超声雾化吸入,B组采取氧气雾化吸入。比较两组患者治疗前后痰液量、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及呼气流量峰值(PEF)]及不良反应发生情况。结果 治疗前,两组痰液量比较差异无统计学意义(P>0.05);治疗第1、2、3周后,两组痰液量少于治疗前,且A组痰液量少于B组,差异有统计学意义(P<0.05)。治疗前,两组FEV1、FVC及PEF比较差异无统计学意义(P>0.05);治疗24 h后,两组FEV1、FVC及PEF均高于治疗前,且A组FEV1(2.2±0.3)L、FVC(3.8±0.2)L及PEF(4.8±0.1)L/s均高于B组的(1.6±0.2)L、(2.5±0.1)L、(4.2±0.5)L/s,差异有统计学意义(P<0.05)。A组不良反应发生率6.52%低于B组的22.22%,差异有统计学意义(P<0.05)。结论 对慢性阻塞性肺疾病患者应用超声雾化吸入后可明显减少痰液量,改善肺功能,不良反应发生少。

Objective To study the clinical efficacy of ultrasonic atomization inhalation and oxygen atomization inhalation in patients with chronic obstructive pulmonary disease. Methods A total of 91 patients with chronic obstructive pulmonary disease were randomly divided into group A(46 cases) and group B(45 cases). Group A took ultrasonic atomization inhalation, and group B took oxygen atomization inhalation. Both groups were compared in terms of sputum output, pulmonary function indexes [forced expiratory volume in the 1 st second(FEV1), forced vital capacity(FVC) and peak expiratory flow(PEF)] before and after treatment, and occurrence of adverse reactions. Results Before treatment, there was no statistically significant difference in sputum output between the two groups(P>0.05). At 1, 2 and 3 weeks after treatment, the sputum output in the two groups was less than that before treatment in this group, and the group A was less than group B. All the differences were statistically significant(P<0.05). Before treatment, there was no statistically significant difference in FEV1, FVC and PEF between the two groups(P>0.05). After 24 h of treatment, the FEV1, FVC and PEF in both groups were higher than those before treatment in this group, and the FEV1(2.2±0.3) L, FVC(3.8±0.2) L and PEF(4.8±0.1)L/s in group A were higher than(1.6±0.2) L,(2.5±0.1) L,(4.2±0.5) L/s in group B. All the differences were statistically significant(P<0.05). The incidence of adverse reactions 6.52% in group A was lower than 22.22% in group B, and the difference was statistically significant(P<0.05). Conclusion The application of ultrasonic atomization inhalation to patients with chronic obstructive pulmonary disease can effectively reduce sputum output, improve pulmonary function, and reduce adverse reactions.