不同浓度罗哌卡因对手术治疗患者的麻醉及镇痛效果观察

Observation of anesthesia and analgesia effect of ropivacaine on surgical patients

目的 观察不同浓度罗哌卡因对手术治疗患者的麻醉及镇痛效果。方法 68例手术治疗患者,随机分为对照组和观察组,各34例。对照组应用0.25%的罗哌卡因进行麻醉,观察组应用0.20%的罗哌卡因进行麻醉。比较两组患者术后不同时间点(术后0.5、6 h)生命体征(平均动脉压、心率、动脉血氧饱和度),不同时间点(术后1、2、4、6 h)视觉模拟评分法(VAS)评分,恢复自主呼吸、苏醒及拔管时间,不良反应发生情况。结果 术后0.5、6 h,两组平均动脉压、心率、动脉血氧饱和度比较差异无统计学意义(P>0.05)。观察组恢复自主呼吸时间(3.5±1.2)min、苏醒时间(3.9±2.0)min和拔管时间(3.4±1.8)min均短于对照组的(6.7±1.3)、(6.7±1.5)、(6.2±1.6)min,差异有统计学意义(P<0.05)。术后1、2、4、6 h,观察组VAS评分分别为(2.55±0.85)、(2.14±0.79)、(2.46±0.48)、(2.62±0.35)分,均明显低于对照组的(4.88±1.55)、(4.16±1.66)、(4.90±1.65)、(4.60±1.75)分,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 手术治疗患者应用0.20%的罗哌卡因镇痛效果理想,恢复自主呼吸、苏醒及拔管时间短,值得临床推广应用。

Objective To observe the anesthesia and analgesia effect of different concentrations of ropivacaine on surgical patients. Methods A total of 68 patients who underwent surgery were randomly divided into control group and observation group, with 34 cases in each group. The control group was anesthetized with 0.25% ropivacaine, and the observation group was anesthetized with 0.20% ropivacaine. Both groups were compared in terms of vital signs(mean arterial pressure, heart rate, arterial oxygen saturation) at different time points(0.5, 6 h after surgery), and visual analogue scale(VAS) score at different time points(1, 2, 4, 6 h after surgery), recovery time of spontaneous breathing, recovery and extubation time, and occurrence of adverse reactions. Results At 0.5, 6 h after surgery, there was no statistically significant difference in mean arterial pressure, heart rate, arterial oxygen saturation between the two groups(P>0.05). The recovery time of spontaneous breathing(3.5±1.2) min, recovery time(3.9±2.0) min and extubation time(3.4±1.8) min in the observation group were all shorter than(6.7±1.3),(6.7±1.5), and(6.2±1.6) min in the control group, and the differences were statistically significant(P<0.05). At 1, 2, 4, 6 h after surgery, the VAS scores of the observation group were(2.55±0.85),(2.14±0.79),(2.46±0.48), and(2.62±0.35) points, which were significantly lower than(4.88±1.55),(4.16±1.66),(4.90±1.65), and(4.60±1.75) points of the control group, and the differences were statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion The application of 0.20% ropivacaine during surgery has ideal anesthetic effect with short recovery time of spontaneous breathing, recovery and extubation time, which is worthy of clinical promotion and application.