益生菌辅助治疗婴幼儿湿疹的临床疗效观察

Clinical efficacy of adjuvant treatment with probiotics in infantile eczema

目的观察益生菌辅助治疗婴幼儿湿疹的临床疗效。方法收集2020年2月~2021年2月江西省景德镇市妇幼保健院儿科收治的婴幼儿湿疹患儿60例(包括门急诊患儿及住院患儿),依据随机数字表法分为对照组和观察组,各30例,对照组给予常规基础治疗,观察组在对照组基础上给予双歧杆菌乳杆菌三联活菌片口服,然后统计分析两组患儿的临床疗效、临床症状改善情况、复发情况、情绪好转时间、皮损消退时间、血清免疫相关细胞因子水平、家长满意度。结果观察组患儿治疗的总有效率93.33%(28/30)显著高于对照组的70.00%(21/30)(P<0.05)。观察组患儿的皮疹密度降低、皮疹数量减少、皮损程度减轻、分布面积减小比例、复发率均显著低于对照组(均P<0.05)。观察组患儿的情绪好转时间、皮损消退时间均显著短于对照组(均P<0.05)。观察组患儿治疗后较治疗前的血清IL-10水平降低幅度、Th1/Th2、IFN-α水平升高幅度均显著高于对照组(均P<0.05)。观察组患儿的家长满意度90.00%(27/30)显著高于对照组的66.67%(20/30)(χ^(2)=4.812,P<0.05)。结论益生菌辅助治疗婴幼儿湿疹的临床疗效显著。

Objective To observe the clinical efficacy of adjuvant treatment with probiotics in infantile eczema.Methods A total of 60 patients with infantile eczema who were admitted to the Department of Pediatrics of Jingdezhen Maternal and Child Health Hospital(including those admitted to the clinics and Emergency Room and those hospitalized)from February 2020 to February 2021 were selected.They were divided into the control group and the observation group using random number table method,with 30 patients in each group.The control group were given routine treatment,and the observation group were given triple viable bifidobacterium lactobacillus tablets orally plus routine treatment.The clinical efficacy,improvement of clinical symptoms,recurrence,time to improvement of mood,time to resolution of skin lesions,serum immune related cytokine levels,and parental satisfaction were analyzed and compared between the two groups.Results The observation group had a significantly higher total effective rate of 93.33%(28/30)than the control group of 70.00%(21/30)(P<0.05).The rash density,number of rashes,degree of rash reduction,reduction proportion of distribution area,and recurrence rate in the observation groups were significantly lower than those in the control group(all P<0.05).The time to improvement of mood and time to resolution of skin lesions in the observation group were significantly shorter than those in the control group(all P<0.05).The reduction of serum IL-10 and improvements of Th1/Th2 and IFN-αin the observation groups were significantly greater than those in the control group(all P<0.05).The observation group had a significantly higher tparental satisfaction of 90.00%(27/30)than the control group of 66.67%(20/30)(χ^(2)=4.812,P<0.05).Conclusions The clinical efficacy of adjuvant therapy with probiotic in infantile eczema is significant.