多烯磷脂酰胆碱联合双歧杆菌乳杆菌三联活菌片对慢性乙肝肝硬化患者免疫功能的影响

Effect of polyene phosphatidylcholine combined with bifidobacterium lactobacillus triple viable tablets on immune function in patients with chronic hepatitis B and liver cirrhosis

目的分析多烯磷脂酰胆碱联合双歧杆菌乳杆菌三联活菌片对慢性乙肝肝硬化患者免疫功能的影响。方法回顾性分析2016年5月~2020年8月在浙江省台州医院门诊进行诊治的100例慢性乙肝肝硬化患者,分为对照组与研究组,每组各50例。对两组患者进行养肝、护肝、抗肝纤维化等基础治疗,对照组患者进行基础治疗并服用双歧杆菌乳杆菌三联活菌片,研究组患者在对照组的基础上口服多烯磷脂酰胆碱,对比两组肝功能指标、肝纤维化指标、炎症因子水平、免疫功能指标、治疗疗效。结果治疗后,研究组的丙氨酸氨基转移酶(ALT)、血清总胆红素(TBIL)、天门冬氨酸氨基转移酶(AST)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层黏蛋白(LN)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-2(MMP-2)、CD8^(+)水平低于对照组(t=16.470、10.965、18.160、10.080、15.400、9.543、14.620、14.250、10.600、4.337,P=0.001),CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组(t=3.015、2.886、4.218,P=0.001),差异均有统计学意义(均P<0.05)。研究组治疗总有效率高于对照组(P<0.05)。结论双歧杆菌乳杆菌三联活菌片、多烯磷脂酰胆碱共同服用使患者的炎症因子水平降低,并使肝功能与免疫功能得到改善,临床效果良好。

Objective The effects of polyene phosphatidylcholine combined with Lactobacillus bifidobacterium triple viable tablets on the immune function of patients with chronic hepatitis B liver cirrhosis were analyzed.Methods A retrospective analysis was performed on 100 patients with chronic hepatitis B cirrhosis treated in the outpatient department of Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University from May 2016 to August 2020,and they were divided into control group and study group(with 50 cases in each group).On two groups of patients with nourishing the liver,protect liver,liver fibrosis foundation treatment,such as the control group patients for treatment and taking bifidobacterium lactobacillus sanlian living bacterium,the team patients in the control group on the basis of oral polyene phosphatidyl choline,compared two groups of liver function,hepatic fibrosis and inflammatory factor levels,immune function,treatment efficacy.Results After treatment,the levels of alanine aminotransferase(ALT),serum total bilirubin(TBIL),aspartate aminotransferase(AST),hyaluronic acid(HA),typeⅢprocollagen(PCⅢ),laminin(LN),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),matrix metalloproteinase-2(MMP-2),CD8^(+)in study group were lower than those in control group(t=16.470,10.965,18.160,10.080,15.400,9.543,14.620,14.250,10.600,4.337,P=0.001).The levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in study group were higher than those in the control group(t=3.015,2.886,4.218,P=0.001),and the difference was statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Conclusion The co-administration of Bifidobacterium Lactobacillus triple viable tablets and polyene phosphatidylcholine can reduce the level of inflammatory factors in patients,and improve liver and immune functions.The clinical effect is good.