疏肝养心健脾汤加减治疗青年失眠伴心悸的临床疗效

Clinical observation of Shuganyangxinjianpi decoction in the treatment of youth insomnia with palpitations

目的观察疏肝养心健脾汤加减对中青年失眠伴心悸的临床疗效。方法选取2018年6月~2020年5月于枣庄矿业集团中心医院中医门诊失眠伴心悸患者84例为研究对象。将患者随机分为观察组和对照组,每组各42例。观察组采用疏肝养心健脾汤加减治疗,对照组使用艾司唑仑片联合心得安治疗,两组患者均干预4周,治疗后评估两组患者中医症状积分、临床疗效、睡眠质量改善情况及安全性评价。结果治疗前两组患者中医证候总积分比较,差异无统计学意义(P>0.05),治疗后观察组证候积分改善明显低于对照组(t=2.611,P=0.011);观察组临床治疗总有效率为88.10%,对照组为64.29%,两组差异无统计学意义(χ^(2)=6.241,P=0.130);治疗前两组患者匹兹堡睡眠质量指数(PSQI)3个维度积分比较,差异无统计学意义(P>0.05);治疗后观察组患者PSQI 3个维度积分明显低于对照组(P<0.05)。结论疏肝养心健脾汤加减能显著改善患者的睡眠质量及中医症状,安全有效,值得在临床推广应用。

Objective To observe the clinical effect of Shuganyangxinjianpi decoction on insomnia with heart palpitations in young and middle-aged people.Methods A total of 84 patients with insomnia and palpitations in Zao Zhuang Mining Group Central Hospital from June 2018 to May 2020 were selected.The patients were randomly divided into observation group and control group with 42 cases each.The observation group was treated with Shuganyangxinjianpi decoction,and the control group was treated with Estazolam tablets combined with propranolol.Both groups of patients were intervened for 4 weeks.After treatment,the TCM symptom scores,clinical efficacy,sleep quality improvement and safety evaluation of the two groups of patients were evaluated.Results The TCM syndromes of patients in the treatment group were improved compared to before treatment.The improvement in syndrome scores of the observation group was significantly lower than that of the control group.All were statistically significant(P<0.05);The differences were statistically significant(t=2.611,P=0.011);the total effective rate of clinical treatment in the observation group was 88.10%and the control group was 64.29%,and the difference between the two groups was not statistically significant(χ^(2)=6.241,P=0.130);the comparison of the three dimensions of the Pittsburgh sleep quality index between the two groups of patients before treatment was not statistically significant(P>0.05).After the treatment,the Pittsburgh sleep quality index of the observation group was significantly lower than the control group(P<0.05).Conclusion Shuganyangxinjianpi decoction could significantly improve the patient′s sleep quality,TCM symptoms,safe and effective.