A组轮状病毒分子分型特点研究进展

Advances in the molecular typing characteristics of group A rotavirus

A组轮状病毒(group A rotavirus,RVA)是5岁以下婴幼儿非细菌性急性胃肠炎最主要的病原体之一。RVA感染所导致的腹泻给全球婴幼儿带来了巨大的疾病负担,目前针对RVA没有特效治疗药物,只能通过接种疫苗来达到预防目的。疫苗的有效性与RVA基因型密切相关,因此,本文对国内外RVA分子分型特点的最新进展进行总结,提供基因型多样性的重要信息,为当前和未来疫苗研制中毒株基因型的选择提供参考。

Group A rotavirus(RVA)is one of the most important pathogens of non-bacterial acute gastroenteritis in infants and children under 5 years of age,and diarrhea caused by RVA infection poses a huge disease burden to infants and children worldwide.The effectiveness of vaccines is closely related to RVA genotypes;therefore,this paper summarizes the recent progress in molecular typing characteristics of RVA at home and abroad to provide important information on genotypic diversity and a reference for the selection of virulent strain genotypes in current and future vaccine development.