猴头健胃灵片相比气滞胃痛颗粒用于治疗慢性胃炎的药物经济学评价

Pharmacoeconomic Evaluation of Houtou Jianweiling Tablet Compared with Qizhiweitong Granule in the Treatment of Chronic Gastritis

目的评价猴头健胃灵片相比气滞胃痛颗粒用于治疗慢性胃炎的有效性和经济性。方法本研究基于文献资料,使用成本-效果分析法,构建马尔可夫模型展开研究,干预产出指标为质量调整生命年(QALY)和第4周有效率,成本项目包括药物治疗成本,经济性评价指标为增量成本-效果比(ICER)。结果猴头健胃灵片相比气滞胃痛颗粒在治疗慢性胃炎方面的增量QALY为0.0018,增量第4周有效率为2.65%,相应ICER分别为73301.12元/QALY和48.33元/1%第4周有效率,其可接受度较好,且不确定性分析显示研究结果较为稳定。结论猴头健胃灵片相比气滞胃痛颗粒用于治疗慢性胃炎具有一定的临床优势和成本-效果优势。

Objective To evaluate the effectiveness and economy of Houtoujianweiling Tablets compared to Gastroparesis Granules in the treatment of chronic gastritis. Methods The study was conducted based on literature data, using cost-effect analysis and Markov model. The clinical outcome indicators were quality-adjusted life year and four-week effective rate, the cost included the cost of pharmacotherapy, and the economic evaluation index was incremental cost-effectiveness ratio(ICER). Results The incremental quality-adjusted life year of Houtoujianweiling Tablets compared with Gastroparesis Granules in the treatment of chronic gastritis was 0.001 8, the incremental four-week effective rate was 2.65%, and the corresponding incremental cost-effectiveness ratios were $73 301.12/qaly and $48.33/1% fourth-week effective rate, respectively, which were acceptable, and the uncertainty analysis showed that the study results were stable. Conclusion Houtoujianweiling Tablets have certain clinical advantages and cost-effectiveness advantages over gastric pain granules for the treatment of chronic gastritis.