坦索罗辛联合索利那新治疗下尿路感染致膀胱过度活动症女性患者的疗效

Efficacy of Tamsulosin Combined with Solifenacin in the Treatment of Bladder Overactivity Caused by Lower Urinary Tract Infection in Women

目的探讨坦索罗辛联合索利那新治疗下尿路感染致膀胱过度活动症女性患者的疗效。方法选取2019年1月至2020年12月于安徽医科大学第一附属医院泌尿外科治疗的单纯性下尿路感染致膀胱过度活动症女性患者96例作为研究对象,采用随机数字表法分为观察组与对照组,各48例。观察组患者予以口服坦索罗辛联合索利那新治疗,对照组患者予以坦索罗辛与安慰剂。治疗前与治疗1个月后进行逼尿无抑制收缩次数、最大膀胱容量及首次膀胱排尿感测定,并采用膀胱过度活动症症状量表(OABSS)对患者临床症状进行评估。结果治疗前两组患者逼尿无抑制收缩次数、最大膀胱容量、首次膀胱排尿感及OABSS各项临床症状评分比较差异无统计学意义(P>0.05);与对照组比较,治疗后观察组最大膀胱容量及首次膀胱排尿感明显升高,且逼尿无抑制收缩次数及OABSS各项临床症状评分显著降低,差异有统计学意义(P<0.05)。结论坦索罗辛联合索利那新对于单纯性下尿路感染致膀胱过度活动症疗效显著,可有效改善患者临床症状与尿动力学参数。

Objective To investigate the clinical value of tamsulosin combined with solinacin in the treatment of bladder overactivity caused by lower urinary tract infection in women. Methods A total of 96 female patients with bladder overactivity caused by simple lower urinary tract infection admitted to department of Pharmacy, the First Affiliated Hospital of Anhui Medical University from January 2019 to December 2020 were selected as the research objects and were randomly divided into a control group and an observation group, with 48 cases in each group. Patients in the observation group received oral tamsulosin combined with solinacine, and patients in the control group received tamsulosin combined with placebo. The number of uninhibited constrictions in forced urine, maximum bladder volume and first bladder urination were measured before and 1 month after treatment, and clinical symptoms were assessed by bladder hyperactivity score(OABSS). Results Before treatment, there were no significant differences in the number of uninhibited urinary contraction, maximum bladder volume, first bladder urination feeling and OABSS score between 2 groups(P>0.05). After treatment, the maximum bladder volume and the first bladder urination were significantly increased in the observation group compared with the control group, and the number of uninhibited contractile times of forced urine and the scores of all clinical symptoms of OABSS were significantly decreased in the observation group(P<0.05).Conclusion Tansulosin combined with Solinacin has a significant effects on bladder hyperactivity caused by simple lower urinary tract infection, which is helpful to further improve the clinical symptoms and urodynamic parameters.