医院常用多种药物联合配伍输液稳定性分析

Analyze the Stability of Infusion Prescription of Multi-Drug Combination in Hospital

目的分析医院常用多种药物联合配伍的输液处方稳定性。方法通过江门市人民医院信息系统提取2017—2019年3年内的临床科室开具的多种药物联合配伍输液处方,统计分析较常用的输液处方,分析得出维生素C注射液与10%氯化钾注射液配伍以及维生素C注射液与维生素B_(6)注射液配伍较常用,并对其6h内的不溶性微粒、pH值进行研究,观察外观变化。结果维生素C注射液与10%氯化钾注射液配伍6 h内不溶性微粒、pH值较稳定,外观无变化。维生素C注射液与维生素B_(6)注射液配伍,6 h内不溶性微粒较稳定,但输液pH值超出药物的稳定pH值范围,外观无变化。结论维生素C注射液与10%氯化钾注射液配伍6 h内性质稳定,临床可以使用。维生素C注射液与维生素B_(6)注射液配伍,其稳定性存在争议,为了临床用药安全,建议分开使用。

Objective To analyze the stability of infusion prescription of multi-drug combination in hospital. Methods The infusion prescriptions of multi-drug combination issued by clinical departments from 2017 to 2019 were extracted from the information system of Jiangmen People ’s Hospital. The more commonly used infusion prescriptions were statistically analyzed, and the results showed that the combination of Vitamin C Injection and 10% Potassium Chloride Injection,Vitamin C Injection and Vitamin B;Injection were more commonly used. The insoluble particles and p H values were studied within 6 hours to observe the appearance changes. Results The insoluble particles, p H value and appearance were stable within 6 hours after Vitamin C Injection was mixed with 10% Potassium Chloride Injection. Vitamin C Injection and Vitamin B;Injection are compatible, insoluble particles within 6 hours are called stable, but the pH value of infusion exceeds the stable pH range of the drug, and the appearance does not change. Conclusion Vitamin C Injection and 10% Potassium Chloride Injection have stable properties within 6 hours and can be used in clinic. The compatibility of Vitamin C Injection and Vitamin B;Injection is controversial. For the safety of clinical use, it is suggested to use it separately.