慢性阻塞性肺疾病患者接种三价季节性流感疫苗后1年免疫持久性

One-year immune persistence following seasonal trivalent influenza vaccination among patients with chronic obstructive pulmonary disease

目的评价慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者接种三价季节性流感疫苗(Trivalent influenza vaccine,TIV)后1年的免疫持久性。方法在河北省唐山市3家医院招募COPD患者,于TIV接种前、接种后5周和1年采集血标本,采用血凝抑制(Hemagglutination inhibition,HI)试验检测血清H1N1、H3N2和B型流感病毒HI抗体,分析抗体保护率和几何平均滴度(Geometric mean titer,GMT)。结果共纳入58名COPD患者,TIV接种后1年H1N1、H3N2、B型流感病毒HI抗体保护率分别为72.4%、91.4%、53.4%(95%CI:59.1%-83.3%、81.0%-97.1%、39.9%-66.7%);GMT(1:)分别为63.0、71.0、33.0(95%CI:42.5-93.3、52.1-96.7、24.0-45.4),分别是接种后5周GMT的0.24、0.35和0.18倍(95%CI:0.17-0.33、0.27-0.44、0.14-0.24)。结论COPD患者接种TIV后1年H1N1和H3N2型流感病毒抗体保护率仍维持在较高水平,但各型病毒抗体GMT大幅下降。

ObjectiveTo explore one-year immune persistence following vaccination with seasonal trivalent influenza vaccine(TIV) among patients with chronic obstructive pulmonary disease(COPD).Methods We recruited COPD patients from three hospitals of Tangshan city, Hebei province and collected blood samples before vaccination with TIV and five weeks and one year after vaccination. We tested sera for influenza antibodies using hemagglutination inhibition( HI) assay to evaluate protection rates and geometric mean antibody titers( GMT).ResultsAmong 58 COPD patients, protection rates of HI antibodies against influenza virus types H1N1, H3N2, and B one year after vaccination were 72. 4%,91. 4%, and 53. 4%(95%CI: 59. 1%-83. 3%, 81. 0%-97. 1%, and 39. 9%-66. 7%), respectively,with GMTs(1:) being 63. 0, 71. 0, and 33. 0(95% CI: 42. 5-93. 3, 52. 1-96. 7, and 24. 0-45. 4),which were 0. 24, 0. 35, and 0. 18 times(95%CI:0. 17-0. 33, 0. 27-0. 44, and 0. 14-0. 24) GMTs 5weeks after vaccination.ConclusionsProtective rates of antibodies against influenza virus H1N1 and H3N2 in COPD patients remained high one year after TIV vaccination while GMTs for all types of influenza virus significantly decreased.