情绪性摄食行为的神经环路调控机制

The central mechanism of emotional eating regulation

摄食行为是机体维持个体生存和从事各种生命活动的保障,它的调控十分复杂,涉及到机体多个系统的协调参与,其中中枢神经系统在摄食调控中起着关键性的作用。中枢神经系统不仅在因饥饿而摄食以维持能量稳态的过程中起关键作用,还调控包括享乐进食在内的情绪性摄食行为。本文综述了中枢神经系统控制摄食行为的进展,主要关注情绪性进食的中枢调控机制,尤其是总结了中枢摄食、奖赏系统藉由各种投射路径和信号分子整合机体的营养、压力、情绪等信息进行摄食调控从而维持机体稳态的全过程。

Feeding behavior is key to supply energy for life activities and thus fundamental for survival.Feeding regulation is very complicated and requires the coordinated involvement of multiple systems of the body,among which the central nervous system(CNS)is of particular importance.The CNS not only controls hunger-related feeding behavior to maintain energy homeostasis,but also regulates emotional eating such as hedonic overeating.Here,we review the central mechanism of emotional eating regulation,with an emphasis on the interaction between the feeding and reward circuits via neural projections and signaling molecules that integrate the metabolic state and emotional salience to control emotional eating.