银屑病合并肾脏损害的发病机制及临床表现

Pathogenesis and manifestations of psoriasis complicated with Kidney damage

银屑病是一种遗传与环境共同作用诱发的免疫介导的慢性、复发性、炎症性、系统性疾病。其发病与遗传、免疫、环境、感染、代谢、药物、精神创伤等多种因素相关。传统的与银屑病相关的共病主要包括心血管疾病、代谢综合征、肥胖、糖尿病、血脂异常和炎症性肠病等,越来越多的研究发现其他一些疾病与银屑病之间的密切关联。本文将就银屑病与肾脏疾病的发病机制及表现方面进行综述。

Psoriasis is an immune-mediated chronic,recurrent,inflammatory and systemic disease induced by a combination of genetics and environment.Its pathogenesis is related to many factors,such as heredity,immunity,environment,infection,metabolism,drugs,mental trauma and so on.The traditional comorbidities associated with psoriasis mainly include cardiovascular disease,metabolic syndrome,obesity,diabetes mellitus,dyslipidemia and inflammatory bowel disease,etc.More and more studies have found that some other diseases are closely associated with psoriasis.The pathogenesis and manifestations of psoriasis and renal diseases are reviewed in this article.